Research progress in the changes and management of myocardial mitochondria during sepsis

doi:10.3877/cma.j.issn.1673-9450.2015.02.014

Abstract

Abstract:

Reduction of cardiac output and systolic function occurs in almost 50% septic patients .Meanwhile, 11.4% of them develop heart failure.Recently, it is believed that structural and functional changes of myocardial mitochondria are the main causes of cardiac systolic function's reduction during sepsis. There have been a lot of the basic and clinical studies on septic changes and management of myocardial mitochondria for a long time. This review tries to summarize the domestic and foreign research progresses in the changes and management concerning the structure and function of myocardial mitochondria, mitophagy as well as apoptosis during sepsis.

Key words: Sepsis, Myocardium, Mitochondria

Xin He, Qin Zhang. Research progress in the changes and management of myocardial mitochondria during sepsis[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2015, 10(02): 175-179.

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