Mitochondrial and intervertebral disc degeneration

doi:10.3877/cma.j.issn.1673-9450.2023.03.016

Abstract

Abstract:

Low back pain has become the leading cause of disability in worldwide, and the incidence is increasing year by year. Intervertebral disc degeneration(IVDD) is the main causative factor of low back pain, but its pathological mechanism is not well understood. Mitochondria are important organelles for energy production in organisms, not only playing an important role in physiological processes, but also participating in the pathological processes of many joint degenerative diseases. However, the mechanism of mitochondrial participation in intervertebral disc degeneration has not yet been elucidated, and this article reviews the research progress of mitochondria in IVDD and corresponding treatment strategies in recent years by reviewing relevant literature.

Key words: Mitochondria, Intervertebral disc degeneration, Programmed cell death, Mitophagy, Research progress

Yongbo Zhang, Liang Zhang, Liuyang Chen, Rui Dai, Hua Sun, Sheng Yang, Bo Meng, Qing Peng. Mitochondrial and intervertebral disc degeneration[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(03): 265-269.

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https://zhssyxfzz.cma-cmc.com.cn/EN/Y2023/V18/I03/265

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