Research progress of the vascularization of the skin flap with adipose-derived stem cells

doi:10.3877/cma.j.issn.1673-9450.2015.05.017

Abstract

Abstract:

Flap transplantation is one of the most widely used and the most effective methods for repair of skin defect in plastic surgery.Early establishment of good circulation is the key method to the survival of the transplanted flap. With the deepening of stem cell research, a growing number of studies have shown that the role of adipose-derived stem cells are precise for the vascularization. In addition, adipose-derived stem cells have some special advantages such as abundant, easy extraction, low immunogenic, no ethical problems, et al. It is verified by experiments gradually that adipose-derived stem cells promot the skin flap vascularization. There are two important mechanisms promoting vasculogenesis and providing good vascularization for the tansplanted flap. In conclusion, These expriments lay a foundation for adipose-derived stem cells clinical applications in the future. Furthor more, adipose-derived stem cells may some day become one of effective methods to prevent flap ischemia and necrosis.

Key words: Stem cells, Surgical flaps, Neovascularization, physiologic, Transplantation

Yuanyuan Zhang, Zhen Liu, Chiyu Jia. Research progress of the vascularization of the skin flap with adipose-derived stem cells[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2015, 10(05): 446-449.

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https://zhssyxfzz.cma-cmc.com.cn/EN/Y2015/V10/I05/446

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