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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2015, Vol. 10 ›› Issue (05): 450-453. doi: 10.3877/cma.j.issn.1673-9450.2015.05.018

Special Issue:

• Review • Previous Articles     Next Articles

Research progress of pseudomonas aeruginosa quorum sensing inhibitors

Junqiang Li1, Chenqi Tang1, Zhaofan Xia1,()   

  1. 1. Department of Burn, Changhai Hospital, the Second Military University, Shanghai 200433, China
  • Received:2015-04-07 Online:2015-10-01 Published:2015-10-01
  • Contact: Zhaofan Xia
  • About author:
    Corresponding author: Xia Zhaofan, Email:

Abstract:

Pseudomonas aeruginosa is an opportunistic pathogen with severe antibiotic resistance problems, challenging the use of traditional antibiotics. Quorum sensing is a phenomenon of cell density dependent control of gene expression which controls the expression of virulence factors and biofilm formation in pseudomonas aeruginosa. Inhibition of quorum sensing can reduce the virulence of pseudomonas aeruginosa but shows no selection pressure thus making it a potential anti-infection strategy which is less likely to cause resistance. This review presents the research progress of pseudomonas aeruginosa quorum sensing inhibitors in recent years.

Key words: Pseudomonas aeruginosa, Quorum sensing, Inhibitor

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