Clinical studies have shown that infection is the main cause of death in patients with extensive deep burns, and the incidence of infection can be significantly reduced by excision of eschar and skin graft covering in the early stage of burns. In view of the relative insufficiency of the autologous skin source in patients with extensive deep burns, allograft skin graft has been received the attention of clinicians during clinical treatment, and its application is also being further expanded. However, it is still necessary to solve the problem of immune tolerance in the allograft skin transplant, so that the transplant effect can reach the ideal state. At present, the known immune tolerance may be related to the allodermal collagen, autologous epidermal cells, immature dendritic cells, keratinocytes and other factors. This study can be used to guide the clinical application, by using the allogeneic skin allograft in the condition of lack of autologous skin source to cover the wound, shorten the course of the disease and reduce hospitalization costs.