Research progress of granzyme B in tissue injury repair

doi:10.3877/cma.j.issn.1673-9450.2021.04.012

Abstract

Abstract:

Previous studies on granzyme B mainly focused on its role in inducing apoptosis of tumor cells or virus-infected cells. In recent years, more and more studies have found that granzyme B can also play a role in the extracellular matrix, leading to poor injury repair. Granzyme B promotes tissue inflammation by inducing the expression of inflammatory factors, destroying vascular integrity and increasing inflammatory cell infiltration, and promotes tissue fibrosis by releasing transforming growth factor-β (TGF-β), activating interleukin (IL)-18 and degrading decorin. The role of granzyme B in injury repair has attracted increasing attention. This article reviews the mechanism of granzyme B in promoting inflammation and fibrosis.

Key words: Granzymes, Inflammation, Fibrosis, Injury repair

Zaiqiang Wang, Faguang Jin, Enqing Fu. Research progress of granzyme B in tissue injury repair[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2021, 16(04): 349-352.

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