Research progress on pathogenic mechanism of Vibrio vulnificus

doi:10.3877/cma.j.issn.1673-9450.2022.01.015

Abstract

Abstract:

Vibrio vulnificus, as an opportunistic pathogen, is common in people with chronic liver disease, diabetes and other basic diseases. The history of seafood exposure is a major feature of Vibrio vulnificus infection. Because of its rapid progress and high mortality, Vibrio vulnificus has increasingly attracted clinical attention. The purpose of this paper is to review the pathogenic mechanism of Vibrio vulnificus infection, and to provide new ideas for clinical diagnosis, treatment and prevention.

Key words: Vibrio vulnificus, Epidemiology, Pathogenic mechanism

Yukun Guo, Yu′an Zhu, Xiaoming Fan, Feng Zhu, Bing Ma. Research progress on pathogenic mechanism of Vibrio vulnificus[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(01): 81-84.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2022.01.015

https://zhssyxfzz.cma-cmc.com.cn/EN/Y2022/V17/I01/81

References 42

[1]	Leng F, Lin S, Wu W, et al. Epidemiology, pathogenetic mechanism, clinical characteristics, and treatment of Vibrio vulnificus infection: a case report and literature review[J]. Eur J Clin Microbiol Infect Dis, 2019, 38(11): 1999-2004.
[2]	Baker-Austin C, Oliver JD. Vibrio vulnificus: new insights into a deadly opportunistic pathogen[J]. Environ Microbiol, 2018, 20(2): 423-430.
[3]	Jones MK, Oliver JD. Vibrio vulnificus: disease and pathogenesis[J]. Infect Immun, 2009, 77(5): 1723-1733.
[4]	Oliver JD. The Biology of Vibrio vulnificus[J]. Microbiol Spectr, 2015, 3(3)．
[5]	洪广亮，卢才教，赵光举，等. 创伤弧菌脓毒症诊疗方案(2018)[J]. 中华急诊医学杂志，2018, 27(6): 594-598.
[6]	Chuang PY, Yang TY, Huang TW, et al. Hepatic disease and the risk of mortality of Vibrio vulnificus necrotizing skin and soft tissue infections: A systematic review and meta-analysis[J]. PLoS One, 2019, 14(10): e0223513.
[7]	高宇，应斌宇，郭蕾. 以皮肤损害为特征表现的创伤弧菌感染23例[J]. 中华皮肤科杂志，2010, 43(6): 374-377.
[8]	卢中秋，卢才教，洪广亮，等. 34例创伤弧菌脓毒症患者的流行病学特点及临床诊治[J]. 中华急诊医学杂志，2009, 18(7): 732-736.
[9]	Chao WN, Tsai CF, Chang HR, et al. Impact of timing of surgery on outcome of Vibrio vulnificus-related necrotizing fasciitis[J]. Am J Surg, 2013, 206(1): 32-39.
[10]	卢才教，郭海雷，洪广亮，等. 早期外科手术治疗对肢体感染脓毒症的预后影响[J]. 中华创伤杂志，2012, 28(4): 321-323.
[11]	Kim BS, Kim JH, Choi S, et al. MARTX Toxin-Stimulated Interplay between Human Cells and Vibrio vulnificus[J]. mSphere, 2020, 5(4): e00659-20.
[12]	Jang SY, Hwang J, Kim BS, et al. Structural basis of inactivation of Ras and Rap1 small GTPases by Ras/Rap1-specific endopeptidase from the sepsis-causing pathogen Vibrio vulnificus[J]. J Biol Chem, 2018, 293(47): 18110-18122.
[13]	Gavin HE, Satchell KJF. RRSP and RID Effector Domains Dominate the Virulence Impact of Vibrio vulnificus MARTX Toxin[J]. J Infect Dis, 2019, 219(6): 889-897.
[14]	Horseman MA, Surani S. A comprehensive review of Vibrio vulnificus: an important cause of severe sepsis and skin and soft-tissue infection[J]. Int J Infect Dis, 2011, 15(3): e157-166.
[15]	Pettis GS, Mukerji AS. Structure, Function, and Regulation of the Essential Virulence Factor Capsular Polysaccharide of Vibrio vulnificus[J]. Int J Mol Sci, 2020, 21(9): 3259.
[16]	Kawasaki T, Kawai T. Toll-like receptor signaling pathways[J]. Front Immunol, 2014, 5: 461.
[17]	Çam S, Brinkmeyer R. Differential expression of vvhA and CPS operon allele 1 genes in Vibrio vulnificus under biofilm and planktonic conditions[J]. Antonie Van Leeuwenhoek, 2020, 113(10): 1437-1446.
[18]	Kim D, Na EJ, Kim JS, et al. Transcriptomic Identification and Biochemical Characterization of HmpA, a Nitric Oxide Dioxygenase, Essential for Pathogenesis of Vibrio vulnificus[J]. Front Microbiol, 2019, 10: 2208.
[19]	Fang FC. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies[J]. Nat Rev Microbiol, 2004, 2(10): 820-832.
[20]	Lee A, Lim HX, Kim MS, et al. Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability[J]. Int J Mol Med, 2018, 41(1): 531-540.
[21]	Atarashi K, Tanoue T, Ando M, et al. Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells[J]. Cell, 2015, 163(2): 367-380.
[22]	Shi Y, Liu XF, Zhuang Y, et al. Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice[J]. J Immunol, 2010, 184(9): 5121-5129.
[23]	Cooper AM. IL-23 and IL-17 have a multi-faceted largely negative role in fungal infection[J]. Eur J Immunol, 2007, 37(10): 2680-2682.
[24]	Flierl MA, Rittirsch D, Gao H, et al. Adverse functions of IL-17A in experimental sepsis[J]. FASEB J, 2008, 22(7): 2198-2205.
[25]	Yuan Y, Feng Z, Wang J. Vibrio vulnificus Hemolysin: Biological Activity, Regulation of vvhA Expression, and Role in Pathogenesis[J]. Front Immunol, 2020, 11: 599439.
[26]	Choi G, Jang KK, Lim JG, et al. The transcriptional regulator IscR integrates host-derived nitrosative stress and iron starvation in activation of the vvhBA operon in Vibrio vulnificus[J]. J Biol Chem, 2020, 295(16): 5350-5361.
[27]	Kawase T, Miura F, Debnath A, et al. Functional analysis of N-terminal propeptide in the precursor of Vibrio vulnificus metalloprotease by using cell-free translational system[J]. Protein Expr Purif, 2018, 149: 13-16.
[28]	Kim JA, Lee MA, Jung YC, et al. Repression of VvpM Protease Expression by Quorum Sensing and the cAMP-cAMP Receptor Protein Complex in Vibrio vulnificus[J]. J Bacteriol, 2018, 200(7): e00526-17.
[29]	Lee MA, Kim JA, Yang YJ, et al. VvpM, an extracellular metalloprotease of Vibrio vulnificus, induces apoptotic death of human cells[J]. J Microbiol, 2014, 52(12): 1036-1043.
[30]	Guo RH, Lim JY, Tra My DN, et al. Vibrio vulnificus RtxA1 Toxin Expression Upon Contact With Host Cells Is RpoS-Dependent[J]. Front Cell Infect Microbiol, 2018, 8: 70.
[31]	Kim BA, Lim JY, Rhee JH, et al. Characterization of Prohibitin 1 as a Host Partner of Vibrio vulnificus RtxA1 Toxin[J]. J Infect Dis, 2016, 213(1): 131-138.
[32]	Lee TH, Kim MH, Lee CS, et al. Protection against Vibrio vulnificus infection by active and passive immunization with the C-terminal region of the RtxA1/MARTXVv protein[J]. Vaccine, 2014, 32(2): 271-276.
[33]	Lo HR, Lin JH, Chen YH, et al. RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis[J]. J Infect Dis, 2011, 203(12): 1866-1874.
[34]	Kuo SY, Chou MC, Lee SL, et al. Vibrio vulnificus RtxA1 modulated calcium flux contributes reduced internalization in phagocytes[J]. Life Sci, 2015, 132: 55-60.
[35]	Guo RH, Im YJ, Shin SI, et al. Vibrio vulnificus RtxA1 cytotoxin targets filamin A to regulate PAK1- and MAPK-dependent cytoskeleton reorganization and cell death[J]. Emerg Microbes Infect, 2019, 8(1): 934-945.
[36]	Datta S, Kenton RJ. Characterization of temperature-dependent hemin uptake receptors HupA and HvtA in Vibrio vulnificus[J]. Microbiologyopen, 2019, 8(10): e905.
[37]	Yun NR, Kim DM. Vibrio vulnificus infection: a persistent threat to public health[J]. Korean J Intern Med, 2018, 33(6): 1070-1078.
[38]	Starks AM, Bourdage KL, Thiaville PC, et al. Use of a marker plasmid to examine differential rates of growth and death between clinical and environmental strains of Vibrio vulnificus in experimentally infected mice[J]. Mol Microbiol, 2006, 61(2): 310-323.
[39]	Okai N, Miyamoto K, Tomoo K, et al. VuuB and IutB reduce ferric-vulnibactin in Vibrio vulnificus M2799[J]. Biometals, 2020, 33(4/5): 187-200.
[40]	Abisado RG, Benomar S, Klaus JR, et al. Bacterial Quorum Sensing and Microbial Community Interactions[J]. mBio, 2018, 9(3): e02331-17.
[41]	Lee W, Lee SH, Kim M, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity[J]. Nat Commun, 2018, 9(1): 1606.
[42]	Kim IH, Kim SY, Park NY, et al. Cyclo-(l-Phe-l-Pro), a Quorum-Sensing Signal of Vibrio vulnificus, Induces Expression of Hydroperoxidase through a ToxR-LeuO-HU-RpoS Signaling Pathway To Confer Resistance against Oxidative Stress[J]. Infect Immun, 2018, 86(9): e00932-17.

Please choose a citation manager

Content to export