To investigate the effect of platelet rich plasma (PRP) on the treatment of anterior thoracic mediastinal infection after thoracotomy.

From January 2018 to April 2019, thirty-two patients with mediastinal infection after thoracotomy were selected, including 19 males and 13 females. The average age of patients was (69.5±19.4) years old, ranging from 53 to 84 years old. After admission, they actively performed surgical debridement and PRP filling, analyzed the patient′s clinical data, treatment process, observed the wound healing and healing time, and combined with the retrieval of relevant literature, systematically stated the PRP treatment of mediastinal infection.

Twenty-nine patients were healed by primary operation, the healing time was 14-25 days, the average healing time was (18.0±1.2) days; the healing time of 2 patients was 42 days and 45 days respectively after reoperation; one patient died of multiple organ failure.

It is difficult to treat the infection of the anterior chest and mediastinum after thoracotomy; PRP can not only completely fill the dead space, but also has the effect of promoting tissue healing and strong anti infective force. It can make the wound well repaired and improve the therapeutic effect. It is a simple, active and effective surgical treatment method.