Research progress on intestinal barrier dysfunction after severe burn

doi:10.3877/cma.j.issn.1673-9450.2023.01.010

Abstract

Abstract:

The intestinal barrier consists of intestinal epithelial barrier, intestinal microbial barrier and mucosal immune barrier. Many factors such as low perfusion ischemia and hypoxia, inflammatory cytokines, malnutrition and flora imbalance after severe burn can lead to intestinal barrier dysfunction, which is responsible for bacterial translocation and intestinal infection and vulnerable to sepsis and multiple organ failure, and seriously affects the prognosis of patients. In recent years, more research progress has been made on the mechanism and harm of intestinal barrier function injury after severe burn, which is reviewed in this paper.

Key words: Burns, Intestinal mucosa, Sepsis, Intestine, Barrier function, Flora imbalance

Dawei Li, Chuanan Shen, Zhaoxing Liu, Yu Zang, Wen Zhang, Jinglong Ma. Research progress on intestinal barrier dysfunction after severe burn[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(01): 65-68.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2023.01.010

https://zhssyxfzz.cma-cmc.com.cn/EN/Y2023/V18/I01/65

References 39

[1]	González Olmo BM, Butler MJ, Barrientos RM. Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health[J]. Nutrients, 2021, 13(1): 196.
[2]	Adiliaghdam F, Cavallaro P, Mohad V, et al. Targeting the gut to prevent sepsis from a cutaneous burn[J]. JCI insight, 2020, 5(19): e137128.
[3]	Haak BW, Prescott HC, Wiersinga WJ. Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis[J]. Front Immunol, 2018, 9: 2042.
[4]	Krentz T, Allen S. Bacterial translocation in critical illness[J]. J Small Anim Pract, 2017, 58(4): 191-198.
[5]	Corcione S, Lupia T, De Rosa FG, et al. Microbiome in the setting of burn patients: implications for infections and clinical outcomes[J]. Burns Trauma, 2020, 8: tkaa033.
[6]	Kuethe JW, Armocida SM, Midura EF, et al. Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury[J]. Shock, 2016, 45(6): 647-652.
[7]	Cannon AR, Akhtar S, Hammer AM, et al. Effects of Mesalamine Treatment on Gut Barrier Integrity After Burn Injury[J]. J Burn Care Res, 2016, 37(5): 283-292.
[8]	罗红敏，胡森，卞徽宁，等. 丙戊酸钠对严重烫伤后肠屏障功能的保护作用及机制[J]. 中华危重病急救医学，2017, 29(3): 221-227.
[9]	Luck ME, Herrnreiter CJ, Choudhry MA. Gut Microbial Changes and their Contribution to Post-Burn Pathology[J]. Shock, 2021, 56(3): 329-344.
[10]	Deitch EA. Gut-origin sepsis: evolution of a concept[J]. Surgeon, 2012, 10(6): 350-356.
[11]	Huang Y, Wang Y, Feng Y, et al. Role of Endoplasmic Reticulum Stress-Autophagy Axis in Severe Burn-Induced Intestinal Tight Junction Barrier Dysfunction in Mice[J]. Front Physiol, 2019, 10: 606.
[12]	Fromm B, Billipp T, Peck LE, et al. A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome[J]. Annu Rev Genet, 2015, 49: 213-242.
[13]	Ke JX, Bian X, Liu H, et al. Edaravone reduces oxidative stress and intestinal cell apoptosis after burn through up-regulating miR-320 expression[J]. Mol Med, 2019, 25(1): 54.
[14]	Wang G, Yao J, Li Z, et al. miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling[J]. Antioxid Redox Signal, 2016, 24(17): 961-973.
[15]	Liu Z, Jiang J, Yang Q, et al. MicroRNA-682-mediated downregulation of PTEN in intestinal epithelial cells ameliorates intestinal ischemia-reperfusion injury[J]. Cell Death Dis, 2016, 7(4): e2210.
[16]	梁晶冰，王裴，冯燕海，等. 丁酸钠对严重烫伤小鼠肠道屏障的作用与相关机制[J]. 中华烧伤杂志，2020, 36(1): 48-53.
[17]	陈宏泽. 正丁酸钠对严重烧伤延迟复苏大鼠肠损伤及氧化应激的影响[D]. 合肥：安徽医科大学，2019.
[18]	Feng Y, Huang Y, Wang Y, et al. Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice[J]. Burns Trauma, 2019, 7: 20.
[19]	Qin C, Jiang Y, Chen X, et al. Dexmedetomidine protects against burn-induced intestinal barrier injury via the MLCK/p-MLC signalling pathway[J]. Burns, 2021, 47(7): 1576-1585.
[20]	He W, Wang Y, Wang P, et al. Intestinal barrier dysfunction in severe burn injury[J]. Burns Trauma, 2019, 7: 24.
[21]	Song Y, Li Y, Xiao Y, et al. Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model[J]. Burns Trauma, 2019, 7: 37.
[22]	Niu L, Qiao W, Hu Z, et al. Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat[J]. Fitoterapia, 2011, 82(3): 323-330.
[23]	Wang ZE, Wu D, Zheng LW, et al. Effects of glutamine on intestinal mucus barrier after burn injury[J]. Am J Transl Res, 2018, 10(11): 3833-3846.
[24]	孙珂岱，董志伟，陈婧，等. 严重烧伤患者早期口服混合肠内营养剂对肠黏膜屏障的作用[J]. 中华烧伤杂志，2015, 31(1): 25-29.
[25]	Liu S, Chen HZ, Xu ZD, et al. Sodium butyrate inhibits the production of HMGB1 and attenuates severe burn plus delayed resuscitation-induced intestine injury via the p38 signaling pathway[J]. Burns, 2019, 45(3): 649-658.
[26]	Feng Y, Wang Y, Wang P, et al. Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy[J]. Cell Physiol Biochem, 2018, 49(1): 190-205.
[27]	刘馨竹，游波，张玉龙，等. 维生素D3对严重烧伤小鼠肠黏膜屏障的作用[J]. 中华烧伤杂志，2019, 35(4): 284-291.
[28]	Huang G, Sun K, Yin S, et al. Burn Injury Leads to Increase in Relative Abundance of Opportunistic Pathogens in the Rat Gastrointestinal Microbiome[J]. Front Microbiol, 2017, 8: 1237.
[29]	Tong LC, Wang Y, Wang ZB, et al. Propionate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Reducing Inflammation and Oxidative Stress[J]. Front Pharmacol, 2016, 7: 253.
[30]	冯燕海，黄亚兰，王裴，等. 短链脂肪酸对内毒素/脂多糖引起的人肠上皮细胞屏障功能损害的作用及相关机制[J]. 中华烧伤杂志，2018, 34(4): 214-218.
[31]	Yan H, Ajuwon KM. Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway[J]. PLoS One, 2017, 12(6): e0179586.
[32]	Qiao YL, Qian JM, Lu QY, et al. Protective effects of butyrate on intestinal ischemia-reperfusion injury in rats[J]. J Surg Res, 2015, 197(2): 324-330.
[33]	郭宏伟，张妮妮，张伟，等. 抗生素诱导的菌群紊乱对幼鼠结肠黏膜屏障及免疫反应的影响[J]. 中华实用儿科临床杂志，2019, 34(7): 505-509.
[34]	Huang Z, Huang Y, Chen J, et al. The role and therapeutic potential of gut microbiome in severe burn[J]. Front Cell Infect Microbiol, 2022, 12: 974259.
[35]	Liu Z, Li N, Fang H, et al. Enteric dysbiosis is associated with sepsis in patients[J]. FASEB J, 2019, 33(11): 12299-12310.
[36]	Larabi A, Barnich N, Nguyen HTT. New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD[J]. Autophagy, 2020, 16(1): 38-51.
[37]	Perdanakusuma DS, Hariani L, Nasser NF, et al. The effect of a single-strain probiotic administration in the treatment of thermal burns patients[J]. Iran J Microbiol, 2019, 11(3): 255-259.
[38]	Li QR, Wang CY, Tang C, et al. Reciprocal interaction between intestinal microbiota and mucosal lymphocyte in cynomolgus monkeys after alemtuzumab treatment[J]. Am J Transplant, 2013, 13(4): 899-910.
[39]	Durazzi F, Sala C, Castellani G, et al. Comparison between 16S rRNA and shotgun sequencing data for the taxonomic characterization of the gut microbiota[J]. Sci Rep, 2021, 11(1): 3030.

Please choose a citation manager

Content to export