Role of miRNA in skeletal development and osteoarthritis

doi:10.3877/cma.j.issn.1673-9450.2023.01.012

Abstract

Abstract:

miRNA are a small non-coding RNA (about 21 nucleotides in size) that regulate gene expression and play an important regulatory role in endochondral osteogenesis, maintenance of articular cartilage homeostasis and the disease progression of osteoarthritis. The study of chondrocyte specific miRNA and their target genes provides new insights into the pathogenesis of endochondral osteogenesis (such as skeletal development) and cartilage related diseases like osteoarthritis. As more and more miRNA′s role in the progression of osteoarthritis has been verified, the application of miRNA in the treatment of osteoarthritis has gradually become a focus of translational medicine research. This article focus on the role of chondrocytes-specific miRNA in bone development and osteoarthritis, and further elucidates the potential of miRNA for the treatment of osteoarthritis.

Key words: MicroRNAs, Osteoarthritis, Genes, Endochondral ossification, Chondral homeostasis

Yao Hao, Li Chen, Yongbin Han, Hong Gao, Shufeng Han. Role of miRNA in skeletal development and osteoarthritis[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(01): 73-77.

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References 58

[1]	Zarzour A, Kim HW, Weintraub NL. Epigenetic Regulation of Vascular Diseases[J]. Arterioscler Thromb Vasc Biol, 2019, 39(6): 984-990.
[2]	Razmara E, Bitaraf A, Yousefi H, et al. Non-Coding RNAs in Cartilage Development: An Updated Review[J]. Int J Mol Sci, 2019, 20(18): 4475.
[3]	Lawrence M, Daujat S, Schneider R. Lateral Thinking: How Histone Modifications Regulate Gene Expression[J]. Trends Genet, 2016, 32(1): 42-56.
[4]	Bartel DP. Metazoan MicroRNAs[J]. Cell, 2018, 173(1): 20-51.
[5]	Grigelioniene G, Suzuki HI, Taylan F, et al. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia[J]. Nat Med, 2019, 25(4): 583-590.
[6]	Swingler TE, Niu L, Smith P, et al. The function of microRNAs in cartilage and osteoarthritis[J]. Clin Exp Rheumatol, 2019, 37 Suppl 120(5): 40-47.
[7]	文星钊，张志奇. 非编码RNA在骨关节炎中的研究进展[J/CD]. 中华关节外科杂志(电子版), 2020, 14(2): 189-195.
[8]	Matsuyama H, Suzuki HI. Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis[J]. Int J Mol Sci, 2019, 21(1): 132.
[9]	Michlewski G, Cáceres JF. Post-transcriptional control of miRNA biogenesis[J]. RNA, 2019, 25(1): 1-16.
[10]	Kobayashi T, Lu J, Cobb BS, et al. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation[J]. Proc Natl Acad Sci U S A, 2008, 105(6): 1949-1954.
[11]	Kobayashi T, Papaioannou G, Mirzamohammadi F, et al. Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage[J]. Osteoarthritis Cartilage, 2015, 23(7): 1214-1220.
[12]	Mirzamohammadi F, Papaioannou G, Kobayashi T. MicroRNAs in cartilage development, homeostasis, and disease[J]. Curr Osteoporos Rep, 2014, 12(4): 410-419.
[13]	史光华，李鹏翠，魏垒，等. miRNAs在关节软骨生长发育过程中作用的研究进展[J]. 中国矫形外科杂志，2013, 21(13): 1324-1327.
[14]	Nakamichi R, Kurimoto R, Tabata Y, et al. Transcriptional, epigenetic and microRNA regulation of growth plate[J]. Bone, 2020, 137: 115434.
[15]	Papaioannou G, Inloes JB, Nakamura Y, et al. let-7 and miR-140 microRNAs coordinately regulate skeletal development[J]. Proc Natl Acad Sci U S A, 2013, 110(35): E3291-3300.
[16]	Wienholds E, Kloosterman WP, Miska E, et al. MicroRNA expression in zebrafish embryonic development[J]. Science, 2005, 309(5732): 310-311.
[17]	Ason B, Darnell DK, Wittbrodt B, et al. Differences in vertebrate microRNA expression[J]. Proc Natl Acad Sci U S A, 2006, 103(39): 14385-14389.
[18]	Miyaki S, Sato T, Inoue A, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis[J]. Genes Dev, 2010, 24(11): 1173-1185.
[19]	Nakamura Y, Inloes JB, Katagiri T, et al. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling[J]. Mol Cell Biol, 2011, 31(14): 3019-3028.
[20]	Bluhm B, Ehlen HWA, Holzer T, et al. miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage[J]. Development, 2017, 144(19): 3562-3577.
[21]	Barter MJ, Tselepi M, Gomez R, et al. Genome-Wide MicroRNA and Gene Analysis of Mesenchymal Stem Cell Chondrogenesis Identifies an Essential Role and Multiple Targets for miR-140-5p[J]. Stem Cells, 2015, 33(11): 3266-3280.
[22]	Sacitharan PK. Ageing and Osteoarthritis[J]. Subcell Biochem, 2019, 91: 123-159.
[23]	卫彦强，石继祥，纪斌，等. 骨性关节炎发病机制的研究进展[J]. 医学综述，2018, 24(5): 838-842.
[24]	Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors[J]. Ann Intern Med, 2000, 133(8): 635-646.
[25]	Liu W, Jiao Y, Tian C, et al. Gene Expression Profiling Studies Using Microarray in Osteoarthritis: Genes in Common and Different Conditions[J]. Arch Immunol Ther Exp (Warsz), 2000, 68(5): 28.
[26]	Wang Y, Shen S, Li Z, et al. MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis[J]. Inflamm Res, 2020, 69(1): 63-73.
[27]	Ito Y, Matsuzaki T, Ayabe F, et al. Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2alpha expression and coordinately regulate cartilage homeostasis[J]. Nat Commun, 2021, 12(1): 4148.
[28]	Woods S, Barter MJ, Elliott HR, et al. miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse[J]. Matrix Biol, 2019, 77: 87-100.
[29]	Xue H, Yu P, Wang WZ, et al. The reduced lncRNA NKILA inhibited proliferation and promoted apoptosis of chondrocytes via miR-145/SP1/NF-kappaB signaling in human osteoarthritis[J]. Eur Rev Med Pharmacol Sci, 2020, 24(2): 535-548.
[30]	Xiao Y, Yan X, Yang Y, et al. Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway[J]. Biomed Pharmacother, 2019, 109: 1569-1577.
[31]	Ntoumou E, Tzetis M, Braoudaki M, et al. Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes[J]. Clin Epigenetics, 2017, 9: 127.
[32]	Yin CM, Suen WC, Lin S, et al. Dysregulation of both miR-140-3p and miR-140-5p in synovial fluid correlate with osteoarthritis severity[J]. Bone Joint Res, 2017, 6(11): 612-618.
[33]	Tardif G, Pelletier JP, Fahmi H, et al. NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis[J]. Arthritis Res Ther, 2013, 15(6): R197.
[34]	Swingler TE, Wheeler G, Carmont V, et al. The expression and function of microRNAs in chondrogenesis and osteoarthritis[J]. Arthritis Rheum, 2012, 64(6): 1909-1919.
[35]	Asahara H. Current Status and Strategy of microRNA Research for Cartilage Development and Osteoarthritis Pathogenesis[J]. J Bone Metab, 2016, 23(3): 121-127.
[36]	Rasheed Z, Rasheed N, Al-Shaya O. Epigallocatechin-3-O-gallate modulates global microRNA expression in interleukin-1beta-stimulated human osteoarthritis chondrocytes: potential role of EGCG on negative co-regulation of microRNA-140-3p and ADAMTS5[J]. Eur J Nutr, 2018, 57(3): 917-928.
[37]	Xiao WF, Li YS, Deng A, et al. Functional role of hedgehog pathway in osteoarthritis[J]. Cell Biochem Funct, 2020, 38(2): 122-129.
[38]	王春理，边森，李刚，等. Indian Hedgehog表达量在大鼠骨关节炎早期变化的研究[J]. 中国骨与关节杂志，2018, 7(8): 619-626.
[39]	Skoda AM, Simovic D, Karin V, et al. The role of the Hedgehog signaling pathway in cancer: A comprehensive review[J]. Bosn J Basic Med Sci, 2018, 18(1): 8-20.
[40]	Guilak F, Nims RJ, Dicks A, et al. Osteoarthritis as a disease of the cartilage pericellular matrix[J]. Matrix Biol, 2018, 71/72: 40-50.
[41]	Mao G, Kang Y, Lin R, et al. Long Non-coding RNA HOTTIP Promotes CCL3 Expression and Induces Cartilage Degradation by Sponging miR-455-3p[J]. Front Cell Dev Biol, 2019, 7: 161.
[42]	Hu S, Zhao X, Mao G, et al. MicroRNA-455-3p promotes TGF-beta signaling and inhibits osteoarthritis development by directly targeting PAK2[J]. Exp Mol Med, 2019, 51(10): 1-13.
[43]	Wang X, Tang K, Wang Y, et al. Elevated microRNA1455p increases matrix metalloproteinase9 by activating the nuclear factorkappaB pathway in rheumatoid arthritis[J]. Mol Med Rep, 2019, 20(3): 2703-2711.
[44]	Li M, Du M, Wang Y, et al. CircRNA Lrp6 promotes cementoblast differentiation via miR-145a-5p/Zeb2 axis[J]. J Periodontal Res, 2021, 56(6): 1200-1212.
[45]	Matsukawa T, Sakai T, Yonezawa T, et al. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes[J]. Arthritis Res Ther, 2013, 15(1): R28.
[46]	Iliopoulos D, Malizos KN, Oikonomou P, et al. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks[J]. PLoS One, 2008, 3(11): e3740.
[47]	Jones SW, Watkins G, Good NLe, et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13[J]. Osteoarthritis Cartilage, 2009, 17(4): 464-472.
[48]	Díaz-Prado S, Cicione C, Muiños-López E, et al. Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes[J]. BMC Musculoskelet Disord, 2012, 13: 144.
[49]	Endisha H, Rockel J, Jurisica I, et al. The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets[J]. JCI Insight, 2018, 3(17): e121630.
[50]	Zhang FQ, Wang Z, Zhang H, et al. MiR-27a alleviates osteoarthritis in rabbits via inhibiting inflammation[J]. Eur Rev Med Pharmacol Sci, 2019, 23(3 Suppl): 89-95.
[51]	Zhang G, Zhou Y, Su M, et al. Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5[J]. Biofactors, 2020, 46(5): 788-802.
[52]	Swingler TE, Niu L, Smith P, et al. The function of microRNAs in cartilage and osteoarthritis[J]. Clin Exp Rheumatol, 2019, 37 Suppl 120(5): 40-47.
[53]	Gu J, Rao W, Huo S, et al. MicroRNAs and long non-coding RNAs in cartilage homeostasis and osteoarthritis[J]. Front Cell Dev Biol, 2022, 10: 1092776.
[54]	Shadid M, Badawi M, Abulrob A. Antisense oligonucleotides: absorption, distribution, metabolism, and excretion[J]. Expert Opin Drug Metab Toxicol, 2021, 17(11): 1281-1292.
[55]	Si HB, Zeng Y, Liu SY, et al. Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats[J]. Osteoarthritis Cartilage, 2017, 25(10): 1698-1707.
[56]	Alcaraz MJ, Megías J, García-Arnandis I, et al. New molecular targets for the treatment of osteoarthritis[J]. Biochem Pharmacol, 2010, 80(1): 13-21.
[57]	Saito T, Fukai A, Mabuchi A, et al. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development[J]. Nat Med, 2010, 16(6): 678-686.
[58]	O′Connor S, Murphy EA, Szwed SK, et al. AGO HITS-CLIP reveals distinct miRNA regulation of white and brown adipose tissue identity[J]. Genes Dev, 2021, 35(9/10): 771-781.

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