To study the relationship between restenosis and serum inflammatory factors in patients with diabetic foot (DF) complicated with arteriosclerosis obliterans after endovascular intervention.

50 patients with DF complicated with lower extremity arteriosclerosis obliterans (LEASO) who comed for a follow-up visit in Department of Peripheral Vascular Surgery, Heilongjiang Provincial Hospital Xiangfang District from January 2020 to December 2022 were enrolled, and a retrospective analysis was carried out. According to whether the patients had restenosis, they were divided into unstenosis (n=21) and restenosis (n=29). Gender, age, diabetes history, body mass index (BMI), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were collected. Analyzed relationship between the levels of high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP9), endothelin-1 (ET1), and high mobility group box 1 (HMGB1) and restenosis in two groups.

HbA1c, vascular stenosis rate, hs-CRP, IL-6, MMP9, ET1 and HMGB1 in restenosis group were higher than those in non-stenosis group, and the differences were significant (P<0.05). The vascular stenosis rate was correlated with hs-CRP (r=0.423, P=0.002), IL-6 (r=0.337, P=0.017), MMP9 (r=0.543, P<0.001), ET1 (r=0.670, P<0.001), HMGB1 (r=0.71, P<0.001), HbA1c (r=0.516, P<0.001). The factors affecting the rate of vascular stenosis were ET1 and HMGB1. The order of AUC size was HMGB1>ET1>MMP9>HbA1c=hs-CRP>IL-6(Z=5.000, P=0.416).

Vascular restenosis in DF patients with LEASO is positively correlated with hs-CRP, IL-6, MMP9 and other inflammatory factors.