To investigate the clinical efficacy of combining human acellular demal mantrix (HADM) with autologous skin transplantation in repairing of diabetic foot wounds.

The data of seven patients with Wagre grade 4 diabetic foot, who were admitted to the Department of Wound Repair and Burns, Bishan Hospital Affiliated to Chongqing Medical University from December 2020 to July 2022, were collected. The patient cohort consisted of four males and three females, aged between 68 and 82 years (average age 74.5 years), with wound areas ranging from 12 cm ×7 cm to 16 cm×12 cm. The duration of the disease varied from 6 months to 2 years, with an average duration of 13 months. All cases underwent HADM combined with autologous skin transplantation for repair purposes. Skin color and survival area of the graft were assessed between 7 and 10 days post-operation, while the survival rate, reoperation rate, and adverse reactions associated with the skin graft were recorded.

The follow-up period for 7 patients ranged from 1 month to 2 years, with a mean duration of 7 months. The average healing time was 9 days, with a reoperation rate of 0. All skin grafts exhibited complete survival without any cases requiring reoperation or adverse reactions, resulting in successful cure and no recurrence. The skin grafts demonstrated a high survival rate ranging from 95% to 100%, and there were no noticeable pigmentation or atrophy observed in the grafted area.

For the large area of skin and soft tissue rupture of diabetic foot, the application of HADM combined with autologous skin composite transplantation has simple operation, high survival rate of postoperative skin graft area, no recurrence, and good repair effect.