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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2025, Vol. 20 ›› Issue (02): 179-183. doi: 10.3877/cma.j.issn.1673-9450.2025.02.017

• Reviews • Previous Articles     Next Articles

Research progress on the influence of depleted uranium on mitochondrial damage

Feng Huang1, Wenrun Li1, Yonghong Ran1, Li Chen1, Hongjia Liu1, Qiuchi Wang1, Yuhui Hao1,()   

  1. 1. Department of Military Preventive Medicine,Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning,400038 Chongqing,China
  • Received:2024-10-29 Online:2025-04-01 Published:2025-04-02
  • Contact: Yuhui Hao

Abstract:

Depleted uranium (DU) is a byproduct of the processing and enrichment of natural uranium, primarily remaining after the extraction of highly concentrated uranium.It is widely used in both military and civilian applications.Once DU enters the human body,it exerts adverse effects on multiple organ systems, including the kidneys, lungs, bones, nervous system, and immune system.Mitochondria are sensitive targets of DU toxicity.The accumulation of DU can lead to damage in the mitochondrial electron transport chain, alterations in membrane permeability and potential, oxidative stress, and calcium ion dysregulation.This review comprehensively summarizes the mitochondrial toxicity of DU and its potential mechanisms, aiming to provide a reference for further research into the mechanisms of DU poisoning and the development of intervention strategies.This article elucidates the mitochondrial toxicity of depleted uranium and its potential mechanisms,aiming to provide a reference for further research into the mechanisms to depleted uranium poisoning and the development of interventianal treatments.

Key words: Depleted uranium, Mitochondrial dysfunction, Apoptosis, Oxidative stress

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