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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2025, Vol. 20 ›› Issue (02): 174-178. doi: 10.3877/cma.j.issn.1673-9450.2025.02.016

• Reviews • Previous Articles     Next Articles

Advances in the mechanism and clinical application of rete ridges microstructure-based grafts in promoting wound healing

Shunxin Jin1, Jiayuecheng Pang1, Shichu Xiao1,()   

  1. 1. Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  • Received:2024-10-13 Online:2025-04-01 Published:2025-04-02
  • Contact: Shichu Xiao

Abstract:

Rete ridges (RRs) are structural units located at the dermal-epidermal junction of the skin, consisting of a base, slope, and tip.By increasing the contact area between the epidermis and dermis,RRs facilitate mechanical interlocking between the two layers, thereby enhancing the mechanical properties and stability of the skin.Additionally, RRs contribute to optimizing nutrient supply, promoting stem cell proliferation and differentiation, and maintaining skin homeostasis.The formation of RRs is regulated by physical stress, cellular tension, and molecular signaling pathways.In skin tissue engineering, the reconstruction of RRs microstructures plays a critical role in promoting wound healing and improving graft performance.Recent advancements have enabled the fabrication of biomaterials and grafts incorporating RRs microstructures through techniques such as photolithography and 3D printing, offering new approaches for wound repair.Despite these advancements, challenges remain in the standardized fabrication of RRs,material selection, cell types, and culture conditions.This review summarizes the structural characteristics,formation mechanisms, and applications of RRs in skin tissue engineering, highlights their significance in wound healing to provide effective technological solutions for complex wound repair.

Key words: Rete ridges, Wound healing, Bioscaffolds, Skin tissue engineering

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