In-situ activation and regeneration of stem cells for promoting repair of skin and soft tissue injuries：a review

doi:10.3877/cma.j.issn.1673-9450.2025.04.014

Abstract

Abstract:

Shortage of skin is the bottleneck for treating large area wounds. Current metheds for repaining skin and soft tissue injuries still can't entirely avoid donor site damage. These methods cannot fundamentally improve the prognosis of patients with extensive soft tissue injury. Because of self-renewal ability， multi-directional differentiation， and reaction to injury， endogenous stem cells play an important role in the process of wound healing and scarless healing. How to recruit, activate, and promote the regeneration and differentiation of endogenous stem cells has been a hot spot of in-situ tissue engineering. Because of biophysical characteristics， some biomaterials can recruit stem cells， and activate stem cell regeneration to promote wound repair. Based on the role of stem cells in the repair of soft tissue injury， this review systematically summarizes the research progress of stem cells in-situ regeneration, in order to provide new ideas for the repair of extensive skin and soft tissue injury in clinical practice.

Key words: Stem cells, In-situ tissue regeneration, Biomaterials, Tissue repair

Fangting Shi, Xirui Tong, Sujie Xie, Shizhao Ji. In-situ activation and regeneration of stem cells for promoting repair of skin and soft tissue injuries：a review[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2025, 20(04): 358-362.

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