The prevalence of diabetes mellitus continues to exhibit a sustained upward trend， accompanied by a concurrent rise in the incidence of diabetic microvascular complications. Conditions such as diabetic foot and diabetic chronic ulcers have shown a marked increase in prevalence. Diabetic chronic ulcers， characterized by prolonged therapeutic duration， not only significantly impair patients' quality of life but also demonstrate crucial pathogenic mechanisms that play a pivotal role in disease progression. Notably， vascular endothelial cells （VECs） dysfunction serves as a central pathological event in the initiation and development of vascular complications， rendering the elucidation of its underlying mechanisms clinically significant. Therefore， hope to provide novel therapeutic targets and interventional strategies for diabetic chronic ulcers by exploring systematic investigation into the molecular mechanisms underlying VECs injury.