Wound healing depends on the dynamic regulation of the immune microenvironment， in which the sequential phenotypic transition of macrophages plays a pivotal role. Platelet-rich plasma （PRP） is a blood-derived biological product enriched with multiple bioactive molecules and has been shown to improve wound healing outcomes by modulating macrophage polarization. This review summarizes the mechanisms by which PRP regulates macrophage recruitment， metabolic reprogramming， and phenotypic transition through multiple platelet-derived secretory systems， including platelet α-granules， dense granules， and extracellular vesicles. The roles of growth factors， metabolic signaling pathways， and exosomes in these processes are also discussed. Furthermore， potential strategies for optimizing PRP based on precise macrophage regulation and their prospective applications in the repair of complex wounds are highlighted.