Preconditioning of mesenchymal stromal cells and its protection mechanism

doi:10.3877/cma.j.issn.1673-9450.2017.02.014

Abstract

Abstract:

Stem cell transplantation has opened up new worlds, with great prospects and hopes for clinical disease treatment, and it has made great progress. However, Bone mesenchyme stem cell therapy has been hindered by both key problems, lack of targetting/poor cell engraftment and apoptosis of the implanted cells, resulting in poor therapeutic effects thereby hampering extensive application of this technology in clinical. The stem cell pre-conditioning has brought new hope to solve these two problems. It has been proved that pretreatment of stem cells can improve its migration, homing and survival ability. To this end, the authours will review the related research.

Key words: Stem cells, Transplantation, Preconditioning, Protection, Mechanism

Hong Huang, Wei Qiu, Minjia Chen, Ya Zhang, Tianchen An, Ming Zhu, Fangqiang Zhu. Preconditioning of mesenchymal stromal cells and its protection mechanism[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2017, 12(02): 138-142.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2017.02.014

https://zhssyxfzz.cma-cmc.com.cn/EN/Y2017/V12/I02/138

References 44

1	Guenou H, Nissan X, Larcher F, et al. Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study[J]. Lancet, 2009, 374(9703):1745-1753.
2	Dabiri G, Heiner D, Falanga V. The emerging use of bone marrow-derived mesenchymal stem cells in the treatment of human chronic wounds[J]. Expert Opin Emerg Drugs, 2013, 18(4):405-419
3	Amiri F, Jahanian-Najafabadi A, Roudkenar MH. In vitro augmentation of mesenchymal stem cells viability in stressful microenvironments[J]. Cell Stress Chaperones, 2015, 20(2):237-251.
4	Yu SP, Wei Z, Wei L. Preconditioning strategy in stem cell transplantation therapy[J]. Transl Stroke Res, 2013, 4(1):76-88.
5	Mastri M, Lin H, Lee T. Enhancing the efficacy of mesenchymal stem cell therapy[J]. World J Stem Cells, 2014, 6(2):82-93.
6	Robey TE, Saiget MK, Reinecke H, et al. Systems approaches to preventing transplanted cell death in cardiac repair[J]. J Mol Cell Cardiol, 2008, 45(4):567-581.
7	Cencioni C, Capogrossi MC, Napolitano M. The SDF-1/CXCR4 axis in stem cell preconditioning[J]. Cardiovasc Res, 2012, 94(3):400-407.
8	Lee S, Choi E, Cha MJ, et al. Cell adhesion and long-Term survival of transplanted mesenchymal stem cells: a prerequisite for cell therapy[J]. Oxid Med Cell Longev, 2015, 2015:632902.
9	Haider HK, Ashraf M. Preconditioning and stem cell survival[J]. J Cardiovasc Transl Res, 2010, 3(2):89-102.
10	Yamaoka M, Yamaguchi S, Suzuki T, et al. Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicin[J]. J Mol Cell Cardiol, 2000, 32(6):881-889.
11	Watanabe S, Arimura Y, Nagaishi K, et al. Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors[J]. J Gastroenterol, 2014, 49(2):270-282.
12	Cai H, Zhang Z, Yang GY. Preconditioned stem cells: a promising strategy for cell-based ischemic stroke therapy[J]. Curr Drug Targets, 2014, 15(8):771-779.
13	Kim SW, Kim HW, Huang W, et al. Cardiac stem cells with electrical stimulation improve ischaemic heart function through regulation of connective tissue growth factor and miR-378[J]. Cardiovascular Res, 2013, 100(Suppl 2):241-251.
14	Yu HM, Zhi JL, Cui Y, et al. Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning groat apoptosis induced by oxidative stress in PC12 cells[J]. Apoptosis, 2006, 11(6):931-941.
15	Mirotsou M, Zhang Z, Deb A, et al. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair[J]. Proc Natl Acad Sci, 2007, 104(5):1643-1648.
16	Wang X, Zhang T, Huang W, et al. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors[J]. Stem Cells, 2009, 27(12):3021-3031.
17	Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway[J]. Annu Rev Pharmacol Toxicol, 2007, 47:89-116.
18	Mohammadzadeh M, Halabian R, Gharehbaghian A, et al. Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity[J]. Cell Stress Chaperones, 2012, 17(5):553-565.
19	Hamedi-Asl P, Halabian R, Bahmani P, et al. Adenovirus-mediated expression of the HO-1 protein within MSCs decreased cytotoxicity and inhibited apoptosis induced by oxidative stresses[J]. Cell Stress Chaperones, 2012, 17(2):181-190.
20	Kiani AA, Abdi J, Halabian R, et al. Over expression of HIF-1α in human mesenchymal stem cells increases their supportive functions for hematopoietic stem cells in an experimental co-culture model[J]. Hematology, 2014, 19(2):85-98.
21	Yu SP, Wei Z, Wei L. Preconditioning strategy in stem cell transplantation therapy[J]. Transl Stroke Res, 2013, 4(1):76-88.
22	Kameritsch P, Pogoda K, Pohl U. Channel-independent influence of connexin 43 on cell migration[J]. Biochim Biophys Acta, 2012, 1818(2):1993-2001.
23	Jaderstad J, Brismar H, Herlenius E. Hypoxia preconditioning increases gap-junctional graft and host communication[J]. Neuroreport, 2010, 21(17):1126-1132.
24	Chen J, Crawford R, Chen C, et al. The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration[J]. Tissue Eng Part B Rev, 2013, 19(6):516-528.
25	Mangi AA, Noiseux N, Kong D, et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infracted hearts[J]. Nat Med, 2003, 9(9):1195-1201.
26	Li W, Ma N, Ong LL, et al. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function[J]. Stem Cells, 2007, 25(8):2118-2127.
27	Yin Q, Jin P, Liu X, et al. SDF-1alpha inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways[J]. Mol Biol Rep, 2011, 38(1):9-16.
28	Liu X, Duan B, Cheng Z, et al. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion[J]. Protein Cell, 2011, 2(10):845-854.
29	Jang MW, Yun SP, Park JH, et al. Cooperation of Epac1/Rap1/Akt and PKA in prostaglandin E(2)-induced proliferation of human umbilical cord blood derived mesenchymal stem cells: involvement of c-Myc and VEGF expression[J]. J Cell Physiol, 2012, 227(12):3756-3767.
30	Bocker W, Docheva D, Prall WC, et al. IKK-2 is required for TNF-alphainduced invasion and proliferation of human mesenchymal stem cells[J]. J Mol Med, 2008, 86(10):1183-1192.
31	Tamama K, Fan VH, Griffith LG, et al. Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells[J]. Stem Cells, 2006, 24(3):686-695.
32	Chavakis E, Koyanagi M, Dimmeler S. Enhancing the outcome of cell therapy for cardiac repair：progress from bench to bedside and back[J]. Circulation, 2010, 121(2):325-335.
33	Ip CK, Cheung AN, Ngan HY, et al. p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells[J]. Oncogene, 2011, 30(21):2420-2432.
34	Jiang P, Enomoto A, Jijiwa M, et al. An actin-binding protein Girdin regulates the motility of breast cancer cells[J]. Cancer Res, 2008, 68(5):1310-1318.
35	Liu X, Duan B, Cheng Z, et al. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion[J]. Protein Cell, 2011, 2(10):845-854.
36	Gnecchi M, He H, Noiseux N, et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement[J]. FASEB J, 2006, 20(6):661-669.
37	Granero-Molto F, Myers TJ, Weis JA, et al. Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects[J]. Stem Cells, 2011, 29(10):1537-1548.
38	Cai L, Johnstone BH, Cook TG, et al. Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization[J]. Stem Cells, 2007, 25(12):3234-3243.
39	Wen Q, Zhou L, Zhou C, et al. Change in hepatocyte growth factor concentration promote mesenchymal stem cell-mediated osteogenic regeneration[J]. J Cell Mol Med, 2011, 16(6):1260-1273.
40	Pasha Z, Wang Y, Sheikh R, et al. Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium[J]. Cardiovasc Res, 2008, 77(1):134-142.
41	Saxena A, Fish JE, White MD, et al. Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction[J]. Circulation, 2008, 117(17):2224-2231.
42	Chen J, Crawford R, Chen C, et al. The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration[J]. Tissue Eng Part B Rev, 2013, 19(6):516-528.
43	Wang CY, Mayo MW, Korneluk RG, et al. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation[J]. Science, 1998, 281(5383):1680-1683.
44	Crisostomo PR, Wang Y, Markel TA, et al. Human mesenchymal stem cells stimulated by TNF-alpha, LPS, or hypoxia produce growth factors by an NF kappa B- but not JNKdependent mechanism[J]. Am J Physiol Cell Physiol, 2008, 294(1):675-682.

[1]	Wanglin Luo, Chuanjun Yang, Guoxing Xu, Jianguo Yu, Weidong Sun, Wenjuan Yan, Zhi Feng. Meta analysis on implantation of different grafting materials in open wedge high tibial osteotomy [J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(06): 818-826.
[2]	Linfeng Liu, Zengtao Wang, Yunpeng Wang, Shuo Zhong, Liwen Hao, Shenqiang Qiu, Chao Chen. Clinical application of combined medial plantar flap and hallux nail bone flap in the reconstruction of Grade V finger defects [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(06): 480-484.
[3]	Cheng Wang, Huijun Zhang, Fengjun Qin, Hui Chen. Comparation of efficacy on meshed skin grafting and ReCell epidermal cell transplantation in the treatment of deep second degree burns [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(06): 498-502.
[4]	Yongpei Chen, Haiyan Zhong, Yong Chen, Min Wang, Qian Wang, Mingli Zou, Siming Yuan. Application of digital subtraction angiography in peroneal artery perforator flap transplantation [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(06): 507-510.
[5]	Linian Han, Jun Wang. Advances in the treatment of radiation-induced skin injury [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(06): 533-537.
[6]	Zhuying Liu, Niangou Zhou, Yongqi Li, Libin Zhou. Combined application of hollow trephine and surgical guide for the preparation of alveolar cavity in autologous tooth transplantation [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(06): 418-423.
[7]	Branch of Organ Transplant of Chinese Medical Association, Branch of Organ Transplant Physicians of Chinese Medical Doctor Association, Shanghai Pharmaceutical Profession Association. Expert Consensus on the Use of Mycophenolic Acid in Chinese Liver and Kidney Transplant Recipients (2023 edition) [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 257-272.
[8]	Wenshi Jiang, Xiangxiang He. Analysis of the development characteristics and discipline construction of organ donation globally and in China [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 280-286.
[9]	Wenqing Lu, Xinyi Chen, Xuefei Ren. Investigation on the quality of life after liver transplantation in children with genetic metabolic diseases [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(05): 287-292.
[10]	Qing Yan, Ying Liu, Feiwen Deng, Huanwei Chen. Effect of microvascular invasion on survival and prognosis of liver transplantation recipients with liver cancer [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 624-629.
[11]	Mei Liao, Hongjun Zhang, Jieyang Jin, Yan Lyu, Jie Ren. Diagnostic value of bedside contrast-enhanced ultrasound for early hepatic artery thrombosis after liver transplantation [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 630-634.
[12]	Binglin Li, Shaocheng Lyu, Fei Pan, Tao Jiang, Hua Fan, Jiantao Kou, Qiang He, Ren Lang. Correlation analysis between pathogenic bacteria of donor liver perfusion fluid and early infection after liver transplantation [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 656-660.
[13]	Lei Lyu, Xiao Feng, Kaiming He, Kaining Zeng, Qing Yang, Haijin Lyu, Huimin Yi, Shuhong Yi, Yang Yang, Binsheng Fu. Value of revised King's score in evaluation of live transplantation timing for children with acute liver failure due to Wilson's disease and literature review [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 661-668.
[14]	Jixin He, Yanni Yang, Jiwei Wang, Jianguo Li, Ming Xie. Research progress on the mechanism of intestinal flora metabolites involved in the occurrence of chronic constipation [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(06): 495-499.
[15]	Tian Li, Hong Xu, Heliang Liu. Progress in research of pneumoconiosis [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(08): 900-905.

Please choose a citation manager

Content to export