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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2024, Vol. 19 ›› Issue (06): 531-535. doi: 10.3877/cma.j.issn.1673-9450.2024.06.014

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Research progress on the construction and application of disease models of lung injury with organoidbased approach

Ziwei Lei1, Ping Ling1, Zong Shen1, Chenru Wei1, Banghui Zhu1, Guosheng Wu1, Yu Sun1,()   

  1. 1.Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433,China
  • Received:2024-03-02 Online:2024-12-01 Published:2024-12-02
  • Contact: Yu Sun

Abstract:

Lung organoids are tissue analogues with a certain spatial structure formed by adult stem cells or pluripotent stem cells under 3D culture conditions, which can simulate the structure and function of human tissues to a certain extent.At present, lung organoids have been applied in the construction of lung injury disease models, especially in inhalation lung injury and lung injury caused by infectious diseases.This paper reviews the construction and application of organoids in lung injury disease models in recent years, in order to provide inspiration for the construction of more lung injury models.

Key words: Organoid, Lung injury, Stem cells, Organ-on-a-chip

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