Research progresses of stem cell in the treatment of intervertebral disc degenerative disease

doi:10.3877/cma.j.issn.1673-9450.2018.02.013

Abstract

Abstract:

Low back pain is a common musculoskeletal symptom associated with intervertebral disc degeneration. However, the conservative treatment or surgical treatment just target the clinical symptoms instead of the pathophysiology involved in the degenerative process. The therapeutic strategies based on stem cells and pathophysiology of the degenerative process can provide a new treatment for intervertebral disc degenerative diseases. The common stem cells include mesenchymal stem cells, induced pluripotent stem cells, hematopoietic stem cells and embryonic stem cells. In literature the potential use of different stem cells for intervertebral disc regeneration in vivo and in vitro has already been reported in reproducible animal models as well as to be safe in human clinical trials. The application of stem cell therapy has shown promise in becoming a powerful tool in the future treatment of intervertebral disc degenerative diseases.

Key words: Stem cells, Intervertebral disk degeneration, Mesenchymal stem cells, Regeneration, Biological treatment

Liping Nan, Xinmin Feng, Liang Zhang, Yang Liu, Feng Wang, Shifeng Zhou. Research progresses of stem cell in the treatment of intervertebral disc degenerative disease[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(02): 134-138.

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