Mechanism and application of extracellular vesicles in diabetic wound repair

doi:10.3877/cma.j.issn.1673-9450.2020.05.013

Abstract

Abstract:

As the incidence of diabetes increases year by year, the social and economic burden of diabetes-related wounds is increasing.Although the number of treatment options has been increasing in the past few decades, the development of new methods and materials with good therapeutic energy efficiency, so as to achieve rapid and high-quality repair of diabetic wounds, especially refractory wounds, is still of great clinical significance and market value.Extracellular vesicles have attracted much attention in "decellular stem cell therapy" and are expected to provide a new method for the treatment of diabetic wounds. This paper reviews its role in wound healing in diabetes, especially its effects on inflammatory response, cell proliferation, migration, angiogenesis, collagen generation and extracellular matrix remodeling, in order to provide new ideas and methods for wound healing in diabetic patients.

Key words: Extracellular vesicles, Diabetic wound, Decellular therapy

Jinghao Feng, Yanan Chen, Mingzhou Yuan, Lei Chen. Mechanism and application of extracellular vesicles in diabetic wound repair[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(05): 397-402.

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