Research progress of extracellular vesicles derived from keratinocytes in wound healing

doi:10.3877/cma.j.issn.1673-9450.2021.05.012

Abstract

Abstract:

Extracellular vesicles(EV) are membranous structures secreted by cells containing a large number of biologically active molecules. As the main mediator of intercellular communication, it participate in the regulation of cell physiological processes. A large number of studies have proved that EV have great potential in wound repair. They mainly promote wound healing by regulating wound inflammation, cell proliferation, migration, and angiogenesis, and wound remodeling. Keratinocytes, as the most important cells in the epidermis, communicate with other skin cells by secreting EV and take part in the wound healing process. Therefore, this paper reviews the recent research progress of keratinocyte-derived EV in wound healing and aims to provide a new sight for their use in related therapeutic approaches.

Key words: Wound healing, Inflammation, Extracellular vesicles, Keratinocytes, Angiogenesis

Jianyu Lu, Shichu Xiao, Zhaofan Xia. Research progress of extracellular vesicles derived from keratinocytes in wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2021, 16(05): 441-444.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2021.05.012

https://zhssyxfzz.cma-cmc.com.cn/EN/Y2021/V16/I05/441

References 35

[1]	Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions[J]. J Invest Dermatol, 2014, 134(6): 1527-1534.
[2]	Blanpain C, Fuchs E. Epidermal stem cells of the skin[J]. Annu Rev Cell Dev Biol, 2006, 22: 339-373.
[3]	Shedoeva A, Leavesley D, Upton Z, et al. Wound Healing and the Use of Medicinal Plants[J]. Evid Based Complement Alternat Med, 2019, 2019: 2684108.
[4]	Laberge A, Arif S, Moulin VJ. Microvesicles: Intercellular messengers in cutaneous wound healing[J]. J Cell Physiol, 2018, 233(8): 5550-5563.
[5]	Cabral J, Ryan AE, Griffin MD, et al. Extracellular vesicles as modulators of wound healing[J]. Adv Drug Deliv Rev, 2018, 129: 394-406.
[6]	van Niel G, D′Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles[J]. Nat Rev Mol Cell Biol, 2018, 19(4): 213-228.
[7]	French KC, Antonyak MA, Cerione RA. Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake[J]. Semin Cell Dev Biol, 2017, 67: 48-55.
[8]	Basu J, Ludlow JW. Exosomes for repair, regeneration and rejuvenation[J]. Expert Opin Biol Ther, 2016, 16(4): 489-506.
[9]	Sjöqvist S, Imafuku A, Gupta D, et al. Isolation and Characterization of Extracellular Vesicles from Keratinocyte Cultures[J]. Methods Mol Biol, 2020, 2109: 35-44.
[10]	Mathieu M, Martin-Jaular L, Lavieu G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication[J]. Nat Cell Biol, 2019, 21(1): 9-17.
[11]	Than UTT, Guanzon D, Broadbent JA, et al. Differential Expression of Keratinocyte-Derived Extracellular Vesicle Mirnas Discriminate Exosomes From Apoptotic Bodies and Microvesicles[J]. Front Endocrinol (Lausanne), 2018, 9: 535.
[12]	Nasiri G, Azarpira N, Alizadeh A, et al. Shedding light on the role of keratinocyte-derived extracellular vesicles on skin-homing cells[J]. Stem Cell Res Ther, 2020, 11(1): 421.
[13]	Than UTT, Leavesley DI, Parker TJ. Characteristics and roles of extracellular vesicles released by epidermal keratinocytes[J]. J Eur Acad Dermatol Venereol, 2019, 33(12): 2264-2272.
[14]	Chavez-Muñoz C, Kilani RT, Ghahary A. Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes[J]. J Cell Physiol, 2009, 221(1): 221-231.
[15]	Sun F, Bi Q, Wang X, et al. Down-regulation of mir-27b promotes angiogenesis and fibroblast activation through activating PI3K/AKT signaling pathway[J]. Wound Repair Regen, 2020, 28(1): 39-48.
[16]	Suh EJ, Remillard MY, Legesse-Miller A, et al. A microRNA network regulates proliferative timing and extracellular matrix synthesis during cellular quiescence in fibroblasts[J]. Genome Biol, 2012, 13(12): R121.
[17]	Wang PH, Huang BS, Horng HC, et al. Wound healing[J]. J Chin Med Assoc, 2018, 81(2): 94-101.
[18]	Zhao R, Liang H, Clarke E, et al. Inflammation in Chronic Wounds[J]. Int J Mol Sci, 2016, 17(12): 2085.
[19]	Han G, Ceilley R. Chronic Wound Healing: A Review of Current Management and Treatments[J]. Adv Ther, 2017, 34(3): 599-610.
[20]	Than UTT, Guanzon D, Leavesley D, et al. Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing[J]. Int J Mol Sci. 2017, 18(5): 956.
[21]	Jiang M, Fang H, Shao S, et al. Keratinocyte exosomes activate neutrophils and enhanc e skin inflammation in psoriasis[J]. FASEB J, 2019, 33(12): 13241-13253.
[22]	Zhou X, Brown BA, Siegel AP, et al. Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing[J]. ACS Nano, 2020, 14(10): 12732-12748.
[23]	Kotzerke K, Mempel M, Aung T, et al. Immunostimulatory activity of murine keratinocyte-derived exosomes[J]. Exp Dermatol, 2013, 22(10): 650-655.
[24]	Piipponen M, Li D, Landén NX. The Immune Functions of Keratinocytes in Skin Wound Healing[J]. Int J Mol Sci, 2020, 21(22): 8790.
[25]	Velnar T, Gradisnik L. Tissue Augmentation in Wound Healing: the Role of Endothelial and Epithelial Cells[J]. Med Arch, 2018, 72(6): 444-448.
[26]	Takeo M, Lee W, Ito M. Wound healing and skin regeneration[J]. Cold Spring Harb Perspect Med, 2015, 5(1): a023267.
[27]	Guo J, Chang C, Li W. The role of secreted heat shock protein-90 (Hsp90) in wound healing - how could it shape future therapeutics[J]. Expert Rev Proteomics, 2017, 14(8): 665-675.
[28]	Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing[J]. J Invest Dermatol, 2007, 127(5): 998-1008.
[29]	Li Q, Zhao H, Chen W, et al. Human keratinocyte-derived microvesicle miRNA-21 promotes skin wound healing in diabetic rats through facilitating fibroblast function and angiogenesis[J]. Int J Biochem Cell Biol, 2019, 114: 105570.
[30]	Rodrigues M, Kosaric N, Bonham CA, et al. Wound Healing: A Cellular Perspective[J]. Physiol Rev, 2019, 99(1): 665-706.
[31]	Sorg H, Tilkorn DJ, Hager S, et al. Skin Wound Healing: An Update on the Current Knowledge and Concepts[J]. Eur Surg Res, 2017, 58(1/2): 81-94.
[32]	Gallant-Behm CL, Piper J, Lynch JM, et al. A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin[J]. J Invest Dermatol, 2019, 139(5): 1073-1081.
[33]	Sjöqvist S, Ishikawa T, Shimura D, et al. Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing[J]. J Extracell Vesicles, 2019, 8(1): 1565264.
[34]	Pessolano E, Belvedere R, Bizzarro V, et al. Annexin A1 Contained in Extracellular Vesicles Promotes the Activation of Keratinocytes by Mesoglycan Effects: An Autocrine Loop Through FPRs[J]. Cells, 2019, 8(7): 753.
[35]	Wang C, Wang M, Xu T, et al. Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration[J]. Theranostics, 2019, 9(1): 65-76.

Please choose a citation manager

Content to export