Epidermal stem cell-derived exosomes for wound repair：a review

doi:10.3877/cma.j.issn.1673-9450.2026.01.010

Abstract

Abstract:

The issue of wound healing is a significant clinical concern that warrants immediate attention. For example， delayed re-epithelialization and hypopigmented scars are manifestations of impaired skin regeneration resulting from suboptimal healing processes. Furthermore， existing prognostic techniques for plastic surgery repair continue to be insufficient in fully addressing these challenges. Epidermal stem cells are situated in the basal layer and have the capacity for self-renewal and multipotent differentiation. Epidermal stem cells derived exosomes regulate and promote the multi-stage wound healing process by carrying abundant bioactive factors. Therefore， it is necessary to conduct a systematic review on the research progress of exosomes derived from epidermal stem cells in wound repair， with the aim of providing references for the development of new therapeutic strategies for acute and chronic wound repair.

Key words: Epidermal stem cell, Exosomes, Wound healing

Zihang Pan, Lihua Yang, Yiqun Sun, Meijun Ding, Ke Xue. Epidermal stem cell-derived exosomes for wound repair：a review[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2026, 21(01): 58-62.

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