观察微动力负压护创敷料对兔Ⅱ度烧伤创面愈合的影响。

健康成年新西兰大耳兔8只，采用电子恒温恒压电烫仪90℃烫其背部12 s造成Ⅱ度烧伤创面，每只兔背部共烫伤4个Ⅱ度烫伤创面。采取左右自身对照，左侧为微动力负压护创敷料的治疗组，右侧为采用凡士林纱布覆盖、无菌纱布包扎的对照组。烫伤后即刻和治疗后第1、3、5、7天共5个时相点分别采集创面皮肤组织标本，干湿重法测定创面组织含水量，采用激光多普勒血流仪测定创面微循环血流量，并观察创面愈合情况。

治疗后第1、3、5、7天，治疗组创面组织含水量显著低于对照组，两组比较差异均有统计学意义(t＝5.067、5.133、4.464、3.875，P＝0.001、0.001、0.003、0.006)，治疗后第3、5、7天，创面微循坏血流量治疗组明显高于对照组，两组比较差异均有统计学意义(t＝－3.155、－4.835、－7.168, P＝0.016、0.020、0.000)。治疗组第14天和第20天的创面愈合率均显著高于对照组，两组比较差异均有统计学意义(t＝－39.052、－11.223，P＝0.000、0.000)，治疗组的创面愈合时间为(20.9±2.2)d，对照组的创面愈合时间为(23.0±2.4)d，两组比较差异有统计学意义(t＝9.379，P＝0.000)。

微动力负压护创敷料可减轻创面水肿，增加兔Ⅱ度烧伤创面微循环血流量，缩短创面愈合时间。

To investigate the effect of micropower vacuum dressingson the healing of rabbit second degree burn wound.

Eight adult healthy rabbits were performed a second degree burn, which was obtained on the dorsal skin using electrons homeothermia burn instrument 90℃ for 12 s. Four wounds were performed symmetrically on the back of each rabbit in a self-control situation. One site was set as the treatment group treated with the micropower vacuum dressings and the other site was the control group, treated with vaseline gauze. Immediately after burn and 1, 3, 5, 7 d postburn, the wounds were harvested and water content was examined by dry to wet weight method. Wound microcirculation blood flow was determined using the laser doppler flowmetry and wound healing process was also detected.

On the 1, 3, 5, 7 d postburn, wound tissue water content in the treatment group was significantly lower than that of the control group, the difference was statistically significant (t=5.067, 5.133, 4.464, 3.875, P=0.001, 0.001, 0.003, 0.006). On the 3 d, 5 d and 7 d postburn, wound microcirculation blood flow in the treatment group was significantly higher than that of the control group, the difference was statistically significant (t=-3.155, -4.835, -7.168, P=0.016, 0.020, 0.000). On the 14 d and 20 d postburn, the wound healing rate in the treatment group was significantly higher than that of the control group the difference was statistically significant (t=-39.052, -11.223, P=0.000, 0.000). In the treatment group, the wound healing time was (20.9±2.2) d, which was shorter than that of the control group, the difference was statistically significant (t=9.379, P=0.000).

Micropower vacuum dressings can reduce tissue edema, increase microcirculatory blood flow of rabbit second degree burn wound, and shorten the time of wound healing.