微动力负压护创敷料对兔Ⅱ度烧伤创面愈合的影响

doi:10.3877/cma.j.issn.1673-9450.2015.02.002

中华损伤与修复杂志(电子版) ›› 2015, Vol. 10 ›› Issue (02) : 103 -106. doi: 10.3877/cma.j.issn.1673-9450.2015.02.002

所属专题：文献；

论著

微动力负压护创敷料对兔Ⅱ度烧伤创面愈合的影响

周波¹, 陈旭林¹^,^†(

), 程浩¹, 方旭¹, 刘晟¹, 王飞¹, 王超¹, 邱乐¹

^1. 230022　合肥，安徽医科大学第一附属医院烧伤科

收稿日期:2015-02-21 出版日期:2015-04-01
通信作者: 陈旭林
基金资助:
国家自然科学基金(81372050)

Effect of micropower vacuum dressings on the healing of rabbit second degree burn wound

Bo Zhou¹, Xulin Chen¹^,^†(), Hao Cheng¹, Xu Fang¹, Sheng Liu¹, Fei Wang¹, Chao Wang¹, Le Qiu¹

^1. Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Received:2015-02-21 Published:2015-04-01
Corresponding author: Xulin Chen
About author:
Corresponding author: Chen Xulin, Email: okcxl@126.com

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目的

观察微动力负压护创敷料对兔Ⅱ度烧伤创面愈合的影响。

方法

健康成年新西兰大耳兔8只，采用电子恒温恒压电烫仪90℃烫其背部12 s造成Ⅱ度烧伤创面，每只兔背部共烫伤4个Ⅱ度烫伤创面。采取左右自身对照，左侧为微动力负压护创敷料的治疗组，右侧为采用凡士林纱布覆盖、无菌纱布包扎的对照组。烫伤后即刻和治疗后第1、3、5、7天共5个时相点分别采集创面皮肤组织标本，干湿重法测定创面组织含水量，采用激光多普勒血流仪测定创面微循环血流量，并观察创面愈合情况。

结果

治疗后第1、3、5、7天，治疗组创面组织含水量显著低于对照组，两组比较差异均有统计学意义(t＝5.067、5.133、4.464、3.875，P＝0.001、0.001、0.003、0.006)，治疗后第3、5、7天，创面微循坏血流量治疗组明显高于对照组，两组比较差异均有统计学意义(t＝－3.155、－4.835、－7.168, P＝0.016、0.020、0.000)。治疗组第14天和第20天的创面愈合率均显著高于对照组，两组比较差异均有统计学意义(t＝－39.052、－11.223，P＝0.000、0.000)，治疗组的创面愈合时间为(20.9±2.2)d，对照组的创面愈合时间为(23.0±2.4)d，两组比较差异有统计学意义(t＝9.379，P＝0.000)。

结论

微动力负压护创敷料可减轻创面水肿，增加兔Ⅱ度烧伤创面微循环血流量，缩短创面愈合时间。

关键词: 烧伤, 水肿, 伤口愈合, 血流量, 微动力负压护创敷料

Objective

To investigate the effect of micropower vacuum dressingson the healing of rabbit second degree burn wound.

Methods

Eight adult healthy rabbits were performed a second degree burn, which was obtained on the dorsal skin using electrons homeothermia burn instrument 90℃ for 12 s. Four wounds were performed symmetrically on the back of each rabbit in a self-control situation. One site was set as the treatment group treated with the micropower vacuum dressings and the other site was the control group, treated with vaseline gauze. Immediately after burn and 1, 3, 5, 7 d postburn, the wounds were harvested and water content was examined by dry to wet weight method. Wound microcirculation blood flow was determined using the laser doppler flowmetry and wound healing process was also detected.

Results

On the 1, 3, 5, 7 d postburn, wound tissue water content in the treatment group was significantly lower than that of the control group, the difference was statistically significant (t=5.067, 5.133, 4.464, 3.875, P=0.001, 0.001, 0.003, 0.006). On the 3 d, 5 d and 7 d postburn, wound microcirculation blood flow in the treatment group was significantly higher than that of the control group, the difference was statistically significant (t=-3.155, -4.835, -7.168, P=0.016, 0.020, 0.000). On the 14 d and 20 d postburn, the wound healing rate in the treatment group was significantly higher than that of the control group the difference was statistically significant (t=-39.052, -11.223, P=0.000, 0.000). In the treatment group, the wound healing time was (20.9±2.2) d, which was shorter than that of the control group, the difference was statistically significant (t=9.379, P=0.000).

Conclusion

Micropower vacuum dressings can reduce tissue edema, increase microcirculatory blood flow of rabbit second degree burn wound, and shorten the time of wound healing.

Key words: Burns, Edema, Wound healing, Blood flow, Micropower vacuum dressings

表1 两组兔背Ⅱ度烧伤创面组织含水量的比较(%，±s)

组别	例数	伤后即刻	伤后1 d	伤后3 d	伤后5 d	伤后7 d
对照组	8	72.51±0.49	75.76± 1.37	74.89± 1.20	73.03± 1.28	71.05±1.03
治疗组	8	72.51±0.35	73.69±0.83	73.21±0.96	71.15±0.95	69.37±0.70
t值	?	－0.680	5.067	5.133	4.464	3.875
P值	?	0.948	0.001	0.001	0.003	0.006

表1 两组兔背Ⅱ度烧伤创面组织含水量的比较(%，±s)

组别	例数	伤后即刻	伤后1 d	伤后3 d	伤后5 d	伤后7 d
对照组	8	72.51±0.49	75.76± 1.37	74.89± 1.20	73.03± 1.28	71.05±1.03
治疗组	8	72.51±0.35	73.69±0.83	73.21±0.96	71.15±0.95	69.37±0.70
t值	?	－0.680	5.067	5.133	4.464	3.875
P值	?	0.948	0.001	0.001	0.003	0.006

表2 两组兔背Ⅱ度烧伤创面组织微循环血流量的比较(PU，±s)

组别	例数	伤后即刻	伤后1 d	伤后3 d	伤后5 d	伤后7 d
对照组	8	160.0±5.8	45.2±3.0	56.2±6.4	62.1± 8.2	63.5 ±13.3
治疗组	8	157.6±4.9	47.1±3.4	73.6±13.5	100.0±17.3	154.1±38.8
t值	?	0.785	－1.095	－3.155	－4.835	－7.168
P值	?	0.458	0.310	0.016	0.020	0.000

表2 两组兔背Ⅱ度烧伤创面组织微循环血流量的比较(PU，±s)

组别	例数	伤后即刻	伤后1 d	伤后3 d	伤后5 d	伤后7 d
对照组	8	160.0±5.8	45.2±3.0	56.2±6.4	62.1± 8.2	63.5 ±13.3
治疗组	8	157.6±4.9	47.1±3.4	73.6±13.5	100.0±17.3	154.1±38.8
t值	?	0.785	－1.095	－3.155	－4.835	－7.168
P值	?	0.458	0.310	0.016	0.020	0.000

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