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中华损伤与修复杂志(电子版) ›› 2016, Vol. 11 ›› Issue (03) : 215 -218. doi: 10.3877/cma.j.issn.1673-9450.2016.03.012

所属专题: 文献

论著

外用重组人粒细胞巨噬细胞集落刺激因子凝胶治疗深Ⅱ度烧伤创面临床疗效观察
温春泉1, 赵筱卓1, 张国安1,()   
  1. 1. 100035 北京大学第四临床医学院
  • 收稿日期:2016-03-12 出版日期:2016-06-01
  • 通信作者: 张国安
  • 基金资助:
    首都临床特色应用研究(Z111107058811098)

Clinical curative effect observation of recombinant human granulocyte-macrophage colony-stimulating factor gel on wound healing in patients with deep partial thickness burns

Chunquan Wen1, Xiaozhuo Zhao1, Guoan Zhang1,()   

  1. 1. the Fourth Clinical Medical College of Peking University, Beijing 100035, China
  • Received:2016-03-12 Published:2016-06-01
  • Corresponding author: Guoan Zhang
  • About author:
    Corresponding author: Zhang Guoan, Email:
引用本文:

温春泉, 赵筱卓, 张国安. 外用重组人粒细胞巨噬细胞集落刺激因子凝胶治疗深Ⅱ度烧伤创面临床疗效观察[J/OL]. 中华损伤与修复杂志(电子版), 2016, 11(03): 215-218.

Chunquan Wen, Xiaozhuo Zhao, Guoan Zhang. Clinical curative effect observation of recombinant human granulocyte-macrophage colony-stimulating factor gel on wound healing in patients with deep partial thickness burns[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2016, 11(03): 215-218.

目的

观察外用重组人粒细胞巨噬细胞集落刺激因子凝胶对深Ⅱ度烧伤创面的治疗效果。

方法

选择2013年12月至2014年11月北京大学第四临床医学院收治的深Ⅱ度烧伤患者50例,烧伤面积为10%~30%总体表面积(TBSA)。采用随机数字表法,将患者分为试验组和对照组,每组各25例。对照组创面行常规清创后应用莫匹罗星软膏涂抹并包扎;试验组创面在常规清创基础上局部外用重组人粒细胞巨噬细胞集落刺激因子凝胶及莫匹罗星软膏后包扎,分别比较两组患者的创面愈合时间,治疗7、14、21、28 d时的创面愈合率,观察两组患者的生命体征和不良反应发生情况。采用χ2检验、t检验对两组患者资料数据进行比较、分析。

结果

试验组创面愈合时间(19.6±2.5)d低于对照组(27.3±3.4)d,差异有统计学意义(t=26.407,P<0.05),伤后7、14、21、28 d试验组创面愈合率分别为(29.8±4.6)%、(74.0±7.1)%、(98.2±2.6)%、(100.0±0.0)%,明显高于对照组(20.6±4.5)%、(52.0±8.2)%、(79.6±5.0)%、(97.3±2.6)%,差异均有统计学意义(t=-7.090、-10.050、-16.289、-4.993,P值均小于0.05)。且用药后两组患者生命体征、血常规、尿常规及肝、肾功能均正常,无不良反应发生。

结论

应用外用重组人粒细胞巨噬细胞集落刺激因子凝胶可加速深Ⅱ度烧伤创面愈合。

Objective

To observe the effect of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) gel for deep partial thickness burns.

Methods

Fifty patients from the Fourth Clinical Medical College of Peking University at December 2013 to November 2014 with deep partial thickness burns at 10%-30% total body surface area (TBSA) were randomly assigned into treatment group (conventional debridement and application of rhGM-CSF and mupirocin ointment) and control group (conventional debridement and application of mupirocin ointment), with each group of 25 cases. The complete wound healing time were compared, and wound healing rate were compared in the treatment of 7th, 14th, 21th, 28th days by Chi-square test and t test, as well as systemic situation and adverse reactions were observed.

Results

The complete wound healing time in the treatment group (19.6±2.5)d was shorter than that in the control group (27.3±3.4)d, the difference was statistically significant(P<0.05). The wound healing rates in the treatment group (29.8±4.6)%, (74.0±7.1)%, (98.2±2.6)% and (100.0±0.0)%, were respectively higher than those in the control group (20.6±4.5)%, (52.0±8.2)%, (79.6±5.0)% and (97.3±2.6)% in the treatment of 7th, 14th, 21th, 28th days, the differences were statistically significant(t=-7.090, -10.050, -16.289, -4.993, P values were less than 0.05). During the research, the vital signs, liver and kidney functions of patients in two groups were all normal without adverse reactions.

Conclusion

Using rhGM-CSF gel can accelerate wound healing in patients with deep partial thickness burn.

表1 两组深Ⅱ度烧伤患者性别、年龄及创面部位比较
表2 两组深Ⅱ度烧伤患者治疗不同时间创面愈合率比较(n=25,%,±s)
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