切换至 "中华医学电子期刊资源库"

中华损伤与修复杂志(电子版) ›› 2021, Vol. 16 ›› Issue (06) : 528 -531. doi: 10.3877/cma.j.issn.1673-9450.2021.06.013

综述

微型皮肤组织的制备与临床应用新进展
高豪杰1, 肖仕初1,()   
  1. 1. 200433 上海,海军军医大学第一附属医院烧伤科
  • 收稿日期:2021-09-23 出版日期:2021-12-01
  • 通信作者: 肖仕初
  • 基金资助:
    国家自然科学基金(81871559,82172201)

New progress in preparation and clinical application of microne skin tissue

Haojie Gao1, Shichu Xiao1,()   

  1. 1. Department of Burns, First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  • Received:2021-09-23 Published:2021-12-01
  • Corresponding author: Shichu Xiao
引用本文:

高豪杰, 肖仕初. 微型皮肤组织的制备与临床应用新进展[J/OL]. 中华损伤与修复杂志(电子版), 2021, 16(06): 528-531.

Haojie Gao, Shichu Xiao. New progress in preparation and clinical application of microne skin tissue[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2021, 16(06): 528-531.

我国原创的微型皮肤组织移植技术应用于修复自体皮源严重匮乏的特大面积深度烧伤创面获得了显著的效果。近年来,国内外研究者基于微型皮肤组织移植理论,不断改良、创新微型皮肤组织移植技术,扩大了其应用领域。本文主要介绍了近年微型皮肤组织的创新制备方法和设备,目前微型皮肤组织在临床其他领域的创新应用的相关研究进展。随着制备方法与流程的规范化、简便化,微型皮肤组织移植技术将被应用于越来越多的临床场景,展示了良好的临床效果和应用前景。

The original micro-skin grafting technology in China has been applied to repair the extremely large and deep burn wounds with severe lack of autologous skin sources and achieved remarkable results. In recent years, researchers at home and abroad have continuously improved and innovated the technology of microne skin transplantation based on the theory of microne skin transplantation, and expanded its application field. This paper mainly introduces the innovative preparation methods and equipment of microne skin tissue in recent years, and the related research progress of the innovative application of microne skin tissue in other clinical fields. With the standardization and simplification of preparation methods and processes, microne skin tissue transplantation will be applied to more and more clinical scenes, showing a good clinical effect and application prospects.

[1]
张明良,曹大鑫,常致德,等. 微粒皮肤移植在大面积烧伤患者中的应用[J]. 中华整形烧伤外科杂志1987, 3(1): 284.
[2]
陈旭,覃凤均,于东宁,等. 微粒皮肤移植术的历史、现状和未来[J/CD]. 中华损伤与修复杂志(电子版), 2019, 14(1): 9-12.
[3]
郑小鹏,肖仕初. 微粒皮移植现状及展望[J/CD]. 中华损伤与修复杂志(电子版), 2016, 11(6): 462-464.
[4]
Kadam D. Novel expansion techniques for skin grafts[J]. Indian J Plast Surg, 2016; 49(1): 5-15.
[5]
Tan M, Woo P. Injection laryngoplasty with micronized dermis: a 10-year experience with 381 injections in 344 patients[J]. Laryngoscope, 2010, 120(12): 2460-2466.
[6]
Trovato L, Monti M, Fante CD, et al. A New Medical Device Rigeneracons Allows to Obtain Viable Micro-Grafts From Mechanical Disaggregation of Human Tissues[J]. J Cell Physiol, 2015, 230(10): 2299-2303.
[7]
Purpura V, Bondioli E, Graziano A, et al. Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation[J]. J Vis Exp, 2016(109): e53579.
[8]
Hamnerius N, Wallin E, Svensson K, et al. Fast and Standardized Skin Grafting of Leg Wounds With a New Technique: Report of 2 Cases and Review of Previous Methods[J]. Eplasty, 2016, 16: e14.
[9]
Hackl F, Bergmann J, Granter SR, et al. Epidermal regeneration by micrograft transplantation with immediate 100-fold expansion[J]. Plast Reconstr Surg, 2012, 129(3): 443e-452e.
[10]
Singh M, Nuutila K, Kruse C, et al. Pixel Grafting: An Evolution of Mincing for Transplantation of Full-Thickness Wounds[J]. Plast Reconstr Surg, 2016, 137(1): 92e-99e.
[11]
肖仕初. 皮片切割设备:中国,CN201821236341.9[P]. 2019-04-09.
[12]
Osborne SN, Schmidt MA, Harper JR. An Automated and Minimally Invasive Tool for Generating Autologous Viable Epidermal Micrografts[J]. Adv Skin Wound Care, 2016, 29(2): 57-64.
[13]
Osborne SN, Schmidt MA, Derrick K, et al. Epidermal micrografts produced via an automated and minimally invasive tool form at the dermal/epidermal junction and contain proliferative cells that secrete wound healing growth factors[J]. Adv Skin Wound Care, 2015, 28(9): 397-405.
[14]
Bassetto F, Turra G, Salmaso R, et al. Autologous injectable dermis: a clinical and histological study[J]. Plast Reconstr Surg, 2013, 131(4): 589e-596e.
[15]
Martin L, Byrnes M, Mcgarry S, et al. Social challenges of visible scarring after severe burn: A qualitative analysis[J]. Burns, 2017, 43(1): 76-83.
[16]
Kaplani K, Koutsi S, Armenis V, et al. Wound healing related agents: Ongoing research and perspectives[J]. Adv Drug Deliv Rev, 2018, 129: 242-253.
[17]
Andrews JP, Marttala J, Macarak E, et al. Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment.[J]. Matrix Biol, 2016, 51: 37-46.
[18]
Svolacchia F, De Francesco F, Trovato L, et al. An innovative regenerative treatment of scars with dermal micrografts[J]. J Cosmet Dermatol, 2016, 15(3): 245-253.
[19]
Erol OO. Facial autologous soft-tissue contouring by adjunction of tissue cocktail injection (micrograft and minigraft mixture of dermis, fascia, and fat)[J]. Plast Reconstr Surg, 2000, 106(6):1375-1387; discussion 1388-1389.
[20]
Bocchiotti MA, Bogetti P, Parisi A, et al. Management of Fournier's gangrene non-healing wounds by autologous skin micrograft biotechnology: a new technique[J]. J Wound Care, 2017, 26(6): 314-317.
[21]
Uehara M, Shimizu F. Progress report for intractable ulcer and osteomyelitis cases using autologous micrografts[J]. SAGE Open Med Case Rep, 2019, 7: 2050313X19848301.
[22]
Armstrong DG, Orgill DP, Galiano R, et al. Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an open-label, single-arm feasibility study in diabetic foot ulcers[J]. Int Wound J, 2020, 17(5): 1366-1375.
[23]
Mundinger GS, Armstrong DG, Smith DJ, et al. Autologous Homologous Skin Constructs Allow Safe Closure of Wounds: A Retrospective, Noncontrolled, Multicentered Case Series[J]. Plast Reconstr Surg Glob Open, 2020, 8(5): e2840.
[24]
Menchini G, Astarita C. Effects of autologous micrografts on stable bilateral vitiligo: A focus on hand lesions[J]. J Dermatol, 2020, 47(12): 1417-1423.
[25]
Gupta DK, Devendra S. Microskin Grafting for Stable Vitiligo of the Penis and Vulva: Near Total Uniform Pigmentation[J]. J Cutan Med Surg, 2015, 19(5): 477-483.
[26]
Ruiz RG, Rosell JMC, Ceccarelli G, et al. Progenitor-cell-enriched micrografts as a novel option for the management of androgenetic alopecia[J]. J Cell Physiol, 2020, 235(5): 4587-4593.
[1] 宋勤琴, 李双汝, 李林, 杜鹃, 刘继松. 间充质干细胞源性外泌体在改善病理性瘢痕中作用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 550-553.
[2] 聂生军, 王钰, 王毅, 鲜小庆, 马生成. 复方倍他米松局部注射联合光动力疗法治疗小型瘢痕疙瘩的临床疗效观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 404-410.
[3] 孙俊锋, 涂家金, 付丹, 蒋满香, 刘金晶, 崔乃硕. 手部烧伤瘢痕挛缩畸形整形术后综合康复联合点阵二氧化碳激光治疗的临床效果[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 411-415.
[4] 蒋敏, 刘馨竹, 李大伟, 冯柏塨, 申传安. 点阵CO2激光联合其他非手术方式治疗痤疮瘢痕有效性的网状荟萃分析[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 429-439.
[5] 刘静, 王燕妮, 王继萍. 儿童毛发移植应用前景及病例讨论[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 368-368.
[6] 温春泉, 陈欣, 尹凯, 赵筱卓, 张琮, 程琳, 陈辉. 旋肩胛动脉穿支皮瓣在烧伤后重度腋窝瘢痕挛缩畸形整形修复治疗中的应用[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 294-298.
[7] 张梦思, 麻艺群, 蒙礼娟, 朱辉, 付晋凤. 压力手套与指蹼加压带及泡沫型硅凝胶贴膜联合应用于儿童瘢痕性并指术后的效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(04): 329-334.
[8] 陈向军, 于丽, 王星, 梁俊青, 吴迪, 李志军. 采用不同方法联合放射治疗修复薄型瘢痕疙瘩的临床疗效分析[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(03): 215-222.
[9] 黄瑞娟, 王睿甲, 杜伟栋, 杨欢, 王宏宇, 巴特. 强脉冲光联合长脉冲1064 nm Nd:YAG激光治疗早期增生性烧伤瘢痕的临床效果[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(02): 119-126.
[10] 苏湘鹏, 王晓, 张基勋, 王超, 董欣欣, 祁永军, 刘振中. YAP蛋白的亚细胞定位在瘢痕疙瘩发生中的作用[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(02): 180-183.
[11] 韩冬. 重视手部烧烫伤后瘢痕挛缩畸形的防治[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(01): 3-7.
[12] 胡瑞斌, 周丹亚, 朱亮, 黄天翔, 沈航崇, 王欣. 人工真皮联合自体刃厚皮移植在手部严重烧伤后瘢痕挛缩治疗中的临床效果[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(01): 8-11.
[13] 李馨, 薛雅心, 樊佳俊, 顾晓丁, 许佳, 韩冬. 体外冲击波在烧伤爪形手整形术后康复治疗中的应用效果[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(01): 12-15.
[14] 蒙礼娟, 麻艺群, 王璐, 张梦思, 范鑫, 许水淋, 杨丽红, 朱辉, 付晋凤. 采用SRT-100放射治疗儿童增生性瘢痕的临床疗效初探[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(01): 16-23.
[15] 程宇欣, 张伟, 孔维诗, 孙瑜. 胶原蛋白敷料在创面修复中应用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(01): 73-77.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?