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中华损伤与修复杂志(电子版) ›› 2026, Vol. 21 ›› Issue (03) : 223 -228. doi: 10.3877/cma.j.issn.1673-9450.2026.03.009

综述

多组学技术在烧伤合并脓毒症诊疗中的研究进展
邢浴泽, 李全, 曹胜军()   
  1. 014010 包头,内蒙古医科大学第三附属医院烧伤外科 内蒙古烧伤医学研究所
  • 收稿日期:2026-01-04 出版日期:2026-06-01
  • 通信作者: 曹胜军
  • 基金资助:
    内蒙古自治区自然科学基金(2024LHMS08051); 公立医院科研联合基金科技项目(2023GLLH0241); 航天医疗健康科技集团有限公司科研项目(2022YK19)

Research progress of multi-omics technologies in the diagnosis and treatment of burn-associated sepsis

Yuze Xing, Quan Li, Shengjun Cao()   

  1. Department of Burn Surgery, the Third Affiliated Hospital of Inner Mongolia Medical University, Burn Medical Institute of Inner Mongolia, Baotou 014010, China
  • Received:2026-01-04 Published:2026-06-01
  • Corresponding author: Shengjun Cao
引用本文:

邢浴泽, 李全, 曹胜军. 多组学技术在烧伤合并脓毒症诊疗中的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2026, 21(03): 223-228.

Yuze Xing, Quan Li, Shengjun Cao. Research progress of multi-omics technologies in the diagnosis and treatment of burn-associated sepsis[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2026, 21(03): 223-228.

多组学技术是多学科联合开展烧伤合并脓毒症发病机制探究与精准诊疗的有效方法。该技术通过多维度和跨学科整合不同组学检测数据实现优势互补,明确疾病分子网络,识别预警指标和分子分型,指导精准医疗和个体化干预。多组学单支或多支联合的研究,从一定程度上揭示了免疫细胞异常、信号通路紊乱的分子特征,为疾病早期诊断和靶向治疗提供了新思路,但仍存在标准不统一、数据分析复杂及临床转化困难等挑战。因此,有必要对多组学技术的应用现状及其作用进行综述,并针对现存问题提出解决思路,旨在为烧伤合并脓毒症的精准诊疗与预后评估提供参考。

Multi-omics technology is an effective collaborative multidisciplinary approach for investigating the pathogenesis and enabling precision diagnosis and treatment of burns complicated with sepsis. Complementarity is achieved by integrating multi-dimensional and interdisciplinary omics data, which clarifies the molecular network of the disease, identifies early warning indicators and molecular subtypes, and guides precision medicine and individualized interventions. Single-omics and integrated multi-omics studies, to a certain extent, have revealed the molecular characteristics of immune cell abnormalities and signaling pathway disorders, providing new ideas for early diagnosis and targeted therapy of the disease. However, challenges such as inconsistent standards, data analysis complexity, and clinical translation barriers still persist. This review summarizes the current application status and functions of multi-omics technologies, and proposes solutions to address these issues, aiming to provide references for the precision diagnosis, treatment, and prognostic evaluation of burns complicated with sepsis.

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