Progress in the research of the relationship between NLRP3 inflammasome and intractable diabetic wound

doi:10.3877/cma.j.issn.1673-9450.2015.05.015

Abstract

Abstract:

The inflammasomes are a kind of intracellular multiprotein complexes found in recent years, which consist of the family of NOD-like receptor or absent n melanoma 2, apoptosis-associated speck-like protein and caspase-1. As an important composition of natural immune system, NLRP3 inflammasome plays a critical role in the development of varieties of inflammatory disease. Persistent infection and high proinflammatory state of the diabetes chronic wound activate NLRP3 inflammasome of wound macrophages, promote the mature and secretion of proinflammatory factor interleukin-1 beta, interleukin-18, interleukin-33 by activating caspase-1 and form a sustained amplified inflammatory response, which is the main reason of impaired diabetic wound healing.

Key words: Diabetes mellitus, Wound healing, Interleukin-1beta, NLRP3 inflammasome

Min Gao, Yan Liu, Xiong Zhang. Progress in the research of the relationship between NLRP3 inflammasome and intractable diabetic wound[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2015, 10(05): 434-438.

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