Various skin defects resulting from all kinds of acute and chronic injury factors, such as mechanical injuries, burns, chronic ulcer and body tumor resection that is very common. Compared to the traditional methods, the advent of skin tissue engineering provides an ideal and promising way for the repair of these skin defects. In the past decades, several kinds of products have been developed and presented good clinical effects. However, some basic science problems emerged and blocked the traditional process of some tissue-engineered skin products. This paper aims to present the critical problems of skin tissue engineering, offering some thought of the related researchers and readers.