Research status of relationship between hydrogen sulfide and mitochondrial injury after the injury of organism

doi:10.3877/cma.j.issn.1673-9450.2018.04.012

Abstract

Abstract:

Mitochondria, as the main sites of cellular oxidative metabolism, and the organelles that supply the main energy of cells, plays an important role in the maintenance of normal physiological functions of cells, and is extremely sensitive to all kinds of injury. Studies at home and abroad have demonstrated that exogenous hydrogen sulfide could protect mitochondria in nerve cells, smooth muscle cells, myocardial cells, epidermis cells, and other intracellular mitochondria under the injury of organism, which can reduce the extent of cell injury to promote the body′s recovery. This article summarizes the specific mechanism of the change of hydrogen sulfide in the cell mitochondria after several important organs injury, and reviews the latest research progress on the reduction of mitochondrial injury by hydrogen sulfide.

Key words: Hydrogen sulfide, Mitochondria, Injury, Oxidative metabolism

Lili Geng, Yi Li. Research status of relationship between hydrogen sulfide and mitochondrial injury after the injury of organism[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(04): 305-307.

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References 30

[1]	Hu LF, Lu M, Hon Wong PT, et al. Hydrogen sulfide: neurophysiology and neuropathology[J]. Antioxid Redox Signal, 2011, 15(2):405-419.
[2]	Park SJ, Kim TH, Lee SH, et al. Expression levels of endogenous hydrogen sulfide are altered in patients with allergic rhinitis[J]. Larynqoscope, 2013, 123(3):557-563.
[3]	Kimura H. Production and physiological effects of hydrogen suifide[J]. Antioxid Redox Signal, 2014, 20(5):783-793.
[4]	李国风，杜全胜，张勤增，等. 硫化氢对局灶性脑缺血大鼠脑组织氧化应激的影响[J]. 河北医药，2016, 38(1):5-8.
[5]	张翀，余丹. 硫化氢治疗脑缺血再灌注损伤的研究进展[J/CD]. 中华临床医师杂志(电子版), 2016, 10(23):3626-3630.
[6]	Pan H, Xie X, Chen D, et al. Protective and biogenesis effects of Sodium hydrosulfide on brain mitoch ondria after cardiac arrest and resuscitation[J]. Eur J Pharmacol, 2014, 741:74-82.
[7]	Li GF, Luo HK, Li LF, et al. Dual effects of hydrogen sulphide on focal cerebral ischaemic injury via modulation of oxidative stress-induced apoptosis[J]. Clin Exp Pharmacol Physiol, 2012, 39(9):765-771.
[8]	陆琦，崔翰斌. 硫化氢和心肌缺血再灌注损伤[J]. 临床心血管病杂志，2016, 32(2):112-115.
[9]	Banu SA, Ravindran S, Kurian GA. Hydrogen sulfide postconditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury[J]. Cell Stress Chaperones, 2016, 21(4):571-582.
[10]	Ravindran S, Ansari Banu S, Kurian GA. Hydrogen sulfide preconditioning shows differential protection towards interfibrillar and subsarcolemmal mitochondria from isolated rat heart subjected torevascularization injury[J]. Cardiovasc Pathol, 2016, 25(4):306-315.
[11]	King AL, Polhemus DJ, Bhushan S, et al. Hydrogen sulfidecytoprotective signaling is endothelial nitric oxide synthasenitric oxide dependent[J]. Proc Natl Acad Sci U S A, 2014, 111(8):3182-3187.
[12]	梁伟杰，陈景福，张稳柱，等. ATP敏感性钾通道在硫化氢抑制高糖引起的心肌细胞损伤中的作用[J]. 中国病理生理杂志，2015, 31(5):785-790.
[13]	Zhang Y, Tang ZH, Ren Z, et al. Hydrogen sulfide，thenext potent preventive and therapeutic agent in aging andage-associated diseases[J]. Mol Cell Biol, 2013, 33(6):1104-1113.
[14]	Hu LF, Lu M, Wu ZY, et al. Hydrogen sulfide inhibits rotenone induced apoptosis ia preservation of mitochondrial function[J]. Mol Pharmacol, 2009, 75(1):27-34.
[15]	刘芳，张建新，李兰芳，等. 硫化氢对急性心肌缺血大鼠心肌线粒体损伤的影响[J]. 中国应用生理学杂志，2011, 27(2):158-162.
[16]	唐小卿，杨春涛，冯鉴强. 第三种气体信号分子硫化氢的神经保护作用研究进展[J]. 中南医学科学杂志，2012, 40(1):1-5.
[17]	Kimura H. Signaling molecules: hydrogen sulfide and polysulfide[J]. Antioxid Redox Signal, 2015, 22(5):362-376.
[18]	Yu YP, Chi XL, Liu LJ. A hypothesis：hydrogen sulfide might be neuroprotective against subarachnoid hemorrhage induced brain injury[J]. ScientificWorldJournal, 2014, 2014:432318.
[19]	Wang JF, Li Y, Song JN, et al. Role of hydrogen sulfide in secondary neuronal injury[J]. Neurochem Int, 2014, 64:37-47.
[20]	Eto K, Asada T, Arima K, et al. Brain hydrogen sulfide is severely decreased in Alzheimers diseas[J]. Biochem Biophys Res Commun, 2002, 293(5):1485-1488.
[21]	唐祎昀，唐小卿. 硫化氢神经生物学作用的研究进展[J]. 生理科学进展，2017, 48(1):42-51.
[22]	Tang XQ, Shen XT, Huang YE, et al. Inhibition of endogenous hydrogen sulfide generation is associated with homocysteine-induced neurotoxicity：role of ERK1/2 activation[J]. J Mol Neurosci, 2011, 45(1):60-67.
[23]	Tang XQ, Shen XT, Huang YE, et al. Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells[J]. Neurosci Res, 2010, 68(3):241-249.
[24]	Li L, Moore PK. Putative biological roles of hydrogen sulfide in health and disease：a breath of not so fresh air[J]. Trends Pharmacol Sci, 2008, 29(2):84-90.
[25]	Nichols CG. KATP channels as molecular sensors of cellular metabolism[J]. Nature, 2006, 440(7083):470-476.
[26]	张浩浩，包金锁. 气体分子硫化氢神经保护作用机制的研究进展[J/CD]. 世界最新医学信息文摘(连续型电子期刊), 2015, 15(57):45, 47.
[27]	Zhao FL, Qiao PF, Yan N, et al. Hydrogen Sulfide Selectively Inhibits gamma-Secretase Activity and Decreases Mitochondrial Abeta Production in Neurons from APP/PS1 Transgenic Mice[J]. Neurochem Res, 2016, 41(5):1145-1159.
[28]	Calvert JW, Elston M, Nicholson CK, et al. Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice[J]. Circulation, 2010, 122(1):11-19.
[29]	唐诚，李毅. 硫化氢促进创面愈合的研究进展[J/CD]. 中华损伤与修复杂志(电子版), 2018, 13(1):69-71.
[30]	李毅，王洪瑾，吴晓伟，等. 硫化氢对严重烧伤大鼠肠道生物屏障的影响[J]. 中华烧伤杂志，2015, 31(1):37-41.

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