Progress in mechanism research and application of microRNA on diabetic foot ulcers

doi:10.3877/cma.j.issn.1673-9450.2019.05.010

Abstract

Abstract:

Diabetic foot ulcers are one of the most common complications of diabetes and there is currently no effective treatment. MicroRNA (miRNA) is a core factor regulating wound healing. It interacts with target genes and participates in the pathological response of key cells (endothelial cells, fibroblasts, keratinocytes) in the healing process of diabetic foot ulcers. This paper reviews the effects of these miRNAs related to diabetic foot ulcers on the key cells, and summarizes the current research on artificially synthesizing specific miRNA to promote wound healing, providing new ideas and methods for clinical treatment of diabetic foot ulcers.

Key words: MicroRNAs, Diabetic foot, Endothelial cells, Fibroblasts, Keratinocytes

Keshen Qu, Huafa Que. Progress in mechanism research and application of microRNA on diabetic foot ulcers[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2019, 14(05): 369-373.

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