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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2021, Vol. 16 ›› Issue (01): 74-77. doi: 10.3877/cma.j.issn.1673-9450.2021.01.015

Special Issue:

• Review • Previous Articles     Next Articles

Research progress of skin fibroblasts in wound healing

Xiujuan He1, Yan Lin1, Qingwu Liu1, Jia Chen1, Ping Li1,()   

  1. 1. Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
  • Received:2020-12-22 Online:2021-02-01 Published:2021-02-01
  • Contact: Ping Li

Abstract:

The skin fibroblasts are the main repair cells involved in wound healing. In recent years, their heterogeneity and their communication with nearby cells have gradually attracted attention. The subgroups of dermal fibroblasts mainly include papillary fibroblasts and reticular fibroblasts, which play different roles in wound healing. The fibroblasts interact with nearby cells through autocrine and paracrine signal molecules to form the wound microenvironment, which affects wound healing. The fibroblasts in chronic wounds show a variety of dysfunctions. This article reviews the origin, phenotype, communication with nearby cells of fibroblasts and their dysfunction in chronic wounds.

Key words: Wound healing, Fibroblasts, Skin

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