To evaluate the clinical effect of ozone gas bath combined with conventional dressing in the treatment of deep partial-thickness burn wounds, and to provide the basis for its clinical application.

From June 2019 to September 2020, 37 patients admitted to Tongren Hospital of Wuhan University & Wuhan Third Hospital within 24 hours after limb burns, with burns area less than 15% total body surface area (TBSA), and in which deep partial-thickness wound exceeded 1% TBSA in each limb were selected. The wounds of each patient was divided into ozone gas bath treatment group(n=37) and control group(n=37) based on the principles of location of symmetry, similarity in size, the same burn depth, and the homogenous contrast. Ozone gas bath treatment group was firstly to ozone fumigation bath for 15 minutes, rinsed with 0.9% sodium chloride solution, then the recombinant human epidermal growth factor (rhEGF) gel was evenly applied, covered with vaseline gauze, wrapped with sterile gauze, and dressing was changed every other day. In the control group, the wound was wet applied with iodophor gauze for 15 minutes, then the same as ozone gas bath treatment group dressing method. The score of pain, the infection rate of bacterial culture, the healing time, and adverse reaction in 2 groups were observed and compared. Data were processed with t test and chi-square test.

Visual analogue scale (VAS) score of ozone gas bath treatment group were significantly lower than those in the control group at 3, 7 and 14 days after treatment, the differences were statistically significant (t=-20.17, -16.82, -16.35; P<0.05). The infection rate in ozone gas bath treatment group were lower than those in the control group at 3, 7 and 14 days after treatment , the differences were statistically significant (χ² =6.51, 7.24, 12.28; P<0.05). At 7, 14 and 21 days after treatment, the wound healing rate of ozone gas bath treatment group were higher than those of the control group, the differences were statistically significant (t=3.86, 5.29, 4.27; P<0.05). The healing time of ozone gas bath treatment group was (18.37±3.18) d, which was shorter than the control group [(23.46±4.95) d], and the difference was statistically significant (t =6.25, P<0.05). There were no adverse reactions in ozone gas bath treatment group and the control group.

After ozone gas bath fumigation treatment on deep partial-thickness burn wounds, the inflammation of the wound is relieved, the pain is relieved obviously, no adverse reaction, the comfort level of patients is improved, and the wound healing can be promoted, which has a certain clinical application prospect.