Abstract:

Objective

To investigate the preparation process and clinical effect of gel platelet-rich plasma （PRP）in the treatment of skin ulcer in patients with systemic lupus erythematosus（SLE）.

Methods

A total of 35 female patients with systemic lupus erythematosus （SLE） accompanied by superficial ulcers，admitted to Department of Wound Repair，Xuzhou Renci Hospital from September 2017 to September 2024，were enrolled.The average age was 32 years （range 25-53 years）， and the duration of ulcers before admission ranged from 1 week to 7 months.The causes of ulcer formation were as follows.In 32 cases， the ulcers developed due to skin abrasions causedby trauma，which subsequently expanded into larger wounds.In 1 case， the ulcer resulted from necrosis and non-healing of the flap at the donor site of a hallux toenail flap used for middle finger reconstruction.And in 2 cases， the ulcers on the buttocks were caused by spontaneous rupture.On admission， the wound area ranged from 2.0 cm×3.5 cm to 7 cm×7 cm， with no exposed bones or tendons observed on the wound surface.After admission， a systemic condition assessment was performed，and rheumatology specialists were consulted to adjust the SLE treatment regimen.Following surgical debridement of the skin ulcers， the wound surface was covered with PRP gel to promote granulation tissue growth and epidermal epithelialization.Simultaneously， the wounds were treated with advanced wound dressings according to the moist wound healing theory.

Results

All 35 patients were treated according to the study plan， without skin grafting or flap repair or other operations covering the wound surface， and the wounds healed smoothly.

Conclusion

In the treatment of ulcers in patients with SLE after surgical debridement， platelet-rich plasma gel is applied to cover the wound surface， and the growth rate of granulation tissue at the wound base is rapid.Subsequently， new dressings are used for wound care，demonstrating significant therapeutic efficacy.This treatment has relatively low surgical difficulty and cost，making it easy to popularize in clinical practice.

Key words: Lupus erythematosus, systemic, Skin ulcer, Platelet-rich plasma