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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2025, Vol. 20 ›› Issue (02): 169-173. doi: 10.3877/cma.j.issn.1673-9450.2025.02.015

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Research progress of decellularized extracellular matrix in skin injury repair

Wei Peng1, Xu Liu1, Jiaqi Liu1,()   

  1. 1. Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China
  • Received:2024-08-15 Online:2025-04-01 Published:2025-04-02
  • Contact: Jiaqi Liu

Abstract:

Decellularized extracellular matrix (dECM) is a type of biological material obtained after the cellular components have been removed from tissues or organs, which is achieved through a decellularization process.Due to its unique physical properties and biochemical cues,it has shown significant potential in the repair of tissue and organ injuries.This article reviews the characteristics of dECM from different sources and its application in skin injury repair,analyzes the role of the physical properties of dECM such as stiffness, porosity, pore size, and surface topography in skin injury repair, summarizes the research progress of allogeneic sources of dECM and their application effects in wound healing, and discusses the future development and challenges of dECM in tissue engineering and clinical therapy.

Key words: Decellularized extracellular matrix, Skin injury repair, Physical properties, Xenogeneic sources, Tissue engineering

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