A review of the application of photodynamic therapy in wound healing

doi:10.3877/cma.j.issn.1673-9450.2025.03.010

Abstract

Abstract:

The abuse of antibiotics and other factors may lead to the failure of wound treatment.Developing innovative and effective therapeutic approaches is of great significance for reducing infectionrelated mortality and improving patient outcomes.Photodynamic therapy （PDT） is a novel method for wound repair， which utilizes photosensitizers combined with specific light sources to irradiate tissues， generating free radicals or reactive oxygen species that induce cell death.PDT promotes wound healing through multiple mechanisms， including killing bacteria， alleviating inflammation， stimulating fibroblast proliferation， and increasing transforming growth factor （TGF-β） levels.Based on these mechanisms， PDT demonstrates promising efficacy in promoting wound healing and tissue remodeling.This article primarily summarizes the basic components of photodynamic therapy and its clinical applications in burn wounds， diabetic ulcers，pressure ulcers， scar wounds， and other types of wounds.

Key words: Wound repair, Photodynamic therapy, Photosensitizer, Burn, Scar

Wenchi Li, Tuo Shen. A review of the application of photodynamic therapy in wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2025, 20(03): 248-253.

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