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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2025, Vol. 20 ›› Issue (03): 260-264. doi: 10.3877/cma.j.issn.1673-9450.2025.03.012

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A review of the effect of wound microenvironment temperature on chronic wound healing

Chunxu Yang1, Yue Zhang2,(), Yingjie Kuang1, Ming Liu2   

  1. 1. 1st Clinical Medical College of Shandong University of Traditional Chinese Medicine,Ji'nan 250014,China
    2. Department of Peripheral Vascular Diseases,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji'nan 250014,China
  • Received:2025-02-07 Online:2025-06-01 Published:2025-06-10
  • Contact: Yue Zhang

Abstract:

The microenvironment of chronic wounds exhibits multiple abnormalities, among which temperature dysregulation is a critical factor impeding wound healing.Chronic wounds typically manifest hypothermic conditions due to impaired blood supply and oxygenation, whereas pathological conditions such as infection and inflammatory responses may induce localized hyperthermia.Systematic investigation of thermal characteristics across various chronic wound types holds significant clinical value for early warning,precise assessment, and prognostic prediction.Elucidation of temperature-mediated influence mechanisms in wound repair and development of targeted temperature modulation strategies could provide the foundation for individualized therapeutic approaches tailored to distinct pathological stages of chronic wounds, ultimately providing novel strategies to enhance tissue regeneration.

Key words: Diabetic foot, Pressure ulcers, Varicose ulcers, Wound microenvironment, Wound temperature

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