Severe burns are often associated with intestinal barrier dysfunction，elevated intestinal permeability，and bacterial and endotoxin translocation from the intestines，which can lead to intestinal tissue damage and increase the incidence of acute intestinal injury. Severe burns also can affect the development of complications such as severe pneumonia，acute kidney injury，cardiac dysfunction，liver injury，also affect the healing of skin wounds, and lead to endocrine disorder. The gut-organ axis refers to a bidirectional regulation system existing between the gut and various organs. The gut-organ axis is a potential carrier of molecular mechanisms that mediate the occurrence and development of a series of severe burn complications. In particular，the metabolic regulation pathways and immune-mediated pathways involved in it will provide important clues for clarifying the mechanism underlying the occurrence and development of severe burn complications.