To observe the clinical effect of nanosilver/porcine acellular dermal matrix dressing on superficial second degree burn wounds.

From January 2014 to December 2015, 90 patients with superficial second degree burn were treated and observed in the Department of Burns and Plastics Surgery, General Hospital of Beijing Military Region. According to the order of admission and random number table, the patients were randomly divided into 3 groups, nanosilver dressing group, porcine acellular dermal matrix dressing group and nanosilver/porcine acellular dermal matrix dressing group, each group of 30 patients. On the day of admission, the wounds areas were calculated by taking pictures and the wound secretion was taken for bacterial culture by using the throat swab, burn wounds were treated with debridement, then apply nanosilver dressing, porcine acellular dermal matrix dressing and nanosilver/porcine acellular dermal matrix dressing on the wounds. On the 5th day after treatment , the wound secretion was taken for bacterial culture by using the throat swab again. Pain score was assessed by asking and observing the changes of pain in patients after dressing change. On the 7th day after treatment, the wounds areas were calculated by taking pictures. The wound healing rate was calculated. Wound healing time was recorded. The data were compared by using one-way ANOVA test, SNK-q test and Chi-square test.

On the 5th day after treatment, the wound bacterial culture results of nanosilver dressing group, porcine acellular dermal matrix dressing group and nanosilver/porcine acellular dermal matrix dressing group were 2(6.6%), 9(30.0%), 1(3.3%), there were significant differences among the three groups(χ²=10.962, P=0.004). The wound bacterial culture result of the nanosilver/porcine acellular dermal matrix dressing group was better than the porcine acellular dermal matrix dressing group, there was significant difference between the two groups(χ²=7.680, P=0.006). The pain scores of nanosilver dressing group, porcine acellular dermal matrix dressing group and nanosilver/porcine acellular dermal matrix dressing group on the 5th day after treatment were [(8.6±0.5)points, (6.6±0.8)points, (0.6±1.3)points], the wound healing rates of the three groups on the 7th day after treatment were [(61.67±18.22)%, (86.77±15.32)%, (99.80±0.56)%], the wound healing time of the three groups were [(11.5±1.3)days, (10.3±0.7)days, (7.3±0.7)days], there were significant differences among the three groups(F=201.7, 19.9, 55.7, P values were all less than 0.05). The pain score of the nanosilver/porcine acellular dermal matrix dressing group on the 5th day after treatment was lower than the other two groups(P values were all less than 0.05), the wound healing rate of the nano-silver/porcine acellular dermal matrix dressing group on the 7th day after treatment was better than the other two groups(P values were all less than 0.05), the wound healing time of the nanosilver/porcine acellular dermal matrix dressing group was shorter than the other two groups(P values were all less than 0.05).

The nanosilver/porcine acellular dermal matrix dressing has the effects of anti-infection, promoting wound healing and reducing the pain when dressing changing.