Application and research of Chitosan oligosaccharide on the diabetic cutaneous wound healing

doi:10.3877/cma.j.issn.1673-9450.2018.04.011

Abstract

Abstract:

The chronic diabetic cutaneous wound healing is the problem of clinical practice and hot point of medical research. The effect of the current wound management is uncertain. It is fortunate that some new approaches and materials such as chitosan oligosaccride are approved along with the evolution of tissue regeneration and biotechnique. The results of chitosan oligosaccride applied on the wound dressing have been reported already and attracted more and more researchers′ attentions. But there are not many research on the chitosan oligosaccride and chronic dibetic wound healinng. In this review, the biological mechanism of chitosan oligosaccride promotion on the wound healing is introduced briefly at first. Secondly, the pathology of diabetic skin wound is described. At last, the research and progress of chitosan oligosaccride on diabetic wound healing are summed up.

Key words: Diabetes mellitus, Wound healing, Chitosan oligosaccharide

Juan Du, Yan Zhao, Mingxiao Hou. Application and research of Chitosan oligosaccharide on the diabetic cutaneous wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2018, 13(04): 300-304.

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References 72

[28]	Chung MJ, Park JK, Park YI. Anti-inflammatory effects of low-molecular weight chitosan oligosaccharides in IgE-antigen complex-stimulated RBL-2H3 cells and asthma model mice[J]. Int Immunopharmacol, 2012, 12(2):453-459.
[29]	Huang B, Xiao D, Tan B, et al. Chitosan Oligosaccharide Reduces Intestinal Inflammation That Involves Calcium-Sensing Receptor (CaSR) Activation in Lipopolysaccharide (LPS)-Challenged Piglets[J]. J Agric Food Chem, 2016, 64(1):245-252.
[30]	刘颖，白娟，柳云恩，等. 壳寡糖对大鼠颅脑冲击伤的保护作用[J]. 中华创伤杂志，2016, 32(12):1130-1136.
[31]	Park PJ, Je JY, Kim SK. Angiotensin I converting enzyme (ACE) inhibitory activity of hetero-chitooligosacchatides prepared from partially different deacetylated chitosans[J]. J Agric Food Chem, 2003, 51(17):4930-4934.
[32]	麻攀，刘洪涛，许青松，等. 壳寡糖缓解甲萘醌诱导巨噬细胞损伤机制初探[J]. 中国生物工程杂志，2011, 31(6):18-21.
[33]	Je JY, Park PJ, Kim SK. Free radical scavenging properties of hetero- chitooloigosaccharides using an ESR spectroscopy[J]. Food Chem Toxicol, 2004, 42(3):381-387.
[34]	Fang IM, Yang CM, Yang CH, et al. Chitosan oligosaccharides prevented retinal ischemia and reperfusion injury via reduced oxidative stress and inflammation in rats[J]. Exp Eye Res, 2015, 130:38-50.
[35]	Lu X, Guo H, Sun L, et al. Protective effects of sulfated chitooligosaccharides with different degrees of substitution in MIN6 cells[J]. Int J Biol Macromol, 2013, 52:92-98.
[36]	Li J, He J, Yu C. Chitosan oligosaccharide inhibits LPS-induced apoptosis of vascular endothelial cells through the BKCa channel and the p38 signaling pathway[J]. Int J Mol Med, 2012, 30(1):157-164.
[37]	阎春玲，王春波，刘万顺. 低分子量可溶性壳寡糖对MC3T3-E1成骨细胞增殖和分化的影响[J]. 中国海洋药物杂志，2010, 29(3):8-11.
[38]	Wang J, Liu G, Chen J, et al. Synthesis of Biocompatible Hydroxyapatite Using Chitosan Oligosaccharide as a Template[J]. Materials (Basel), 2015, 8(12):8097-8105.
[39]	沈若武，王守彪，夏玉军. 壳寡糖对新西兰兔骨折愈合的影响[J]. 解剖学杂志，2005, 28(3):340-342.
[40]	Wang X, Wei J, Chen J, et al. Tuning of the surface biological behavior of poly(L-lactide)-based composites by the incorporation of polyelectrolyte complexes for bone regeneration[J]. J Biomater Sci Polym Ed, 2017, 28(15):1713-1727.
[41]	Chen CC, Wang WC, Ding SJ. In vitro physiochemical properties of a biomimetic gelatin/chitosan oligosaccharide/calcium silicate cement[J]. J Biomed Mater Res B Appl Biomater, 2010, 95(2):456-465.
[42]	Ding SJ, Shie MY, Hoshiba T, et al. Osteogenic differentiation and immune response of human bone-marrow-derived mesenchymal stem cells on injectable calcium-silicate-based bone grafts[J]. Tissue Eng Part A, 2010, 16(7):2343-2354.
[43]	Liu B, Liu WS, Han BQ, et al. Antidiabetic effects of chitooligosaccharides on pancreatic islet cells in streptozotocin-induced diabetic rats[J]. World J Gastroenterol, 2007, 13(5):725-731.
[44]	Kim HJ, Ahn HY, Kwak JH, et al. The effects of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes[J]. Food Funct, 2014, 5(10):2662-2669.
[45]	Ju C, Yue W, Yang Z, et al. Antidiabetic effect and mechanism of chitooligosaccharides[J]. Biol Pharm Bull, 2010, 33(9):1511-1516.
[46]	Kim JN, Chang IY, Kim HI, et al. Long-term effects of chitosan oligosaccharide in streptozotocin-induced diabetic rats[J]．Islets, 2009, 1(2):111-116.
[47]	Yuan WP, Liu B, Liu CH, et al. Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats[J]. World J Gastroenterol, 2009, 15(11):1339-1345.
[48]	Lee HW, Park YS, Choi JW, et al. Antidiabetic effects of chitosan oligosaccharides in neonatal streptozotocin-induced noninsulin-dependent diabetes mellitus in rats[J]. Biol Pharm Bull, 2003, 26(8):1100-1103.
[49]	张长梅，于抒含，张良栓，等. 不同分子量壳寡糖的制备及其生物活性的研究[J]. 哈尔滨医科大学学报，2013, 47(6):486-489.
[50]	Yuan WP, Liu B, Liu CH, et al. Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats[J]. World J Gastroenterol, 2009, 15(11):1339-1345.
[51]	Kim JG, Jo SH, Ha KS, et al. Effect of long-term supplementation of low molecular weight chitosan oligosaccharide (GO2KA1) on fasting blood glucose and HbA1c in db/db mice model and elucidation of mechanism of action[J]. BMC Complement Altern Med, 2014, 14:272.
[52]	Jo SH, Ha KS, Moon KS, et al. Molecular weight dependent glucose lowering effect of low molecular weight Chitosan Oligosaccharide (GO2KA1) on postprandial blood glucose level in SD rats model[J]. Int J Mol Sci, 2013, 14(7):14214-14224.
[53]	Yu SY, Kwon YI, Lee C, et al. Antidiabetic effect of chitosan oligosaccharide (GO2KA1) is mediated via inhibition of intestinal alpha-glucosidase and glucose transporters and PPARγ expression[J]. Biofactors, 2017, 43(1):90-99.
[54]	曲婉秋，唐晓琳，王秀武. 壳寡糖鳌合铬对糖尿病小鼠降血糖作用的研究[J]. 天然产物研究与开发，2012, 24(5):605-609.
[55]	刘冰，秦贞奎，林祥梅，等. 壳寡糖及其配合物对胰岛细胞增殖、胰岛素分泌的促进作用[J]. 中国组织工程研究与临床康复，2009, 13(3):513-516.
[56]	Li C, Fu R, Yu C, et al. Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study[J]. Int J Nanomedicine, 2013, 8:4131-4145.
[57]	Li CW, Wang Q, Li J, et al. Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway[J]. Int J Nanomedicine, 2016, 21(11):373-386.
[1]	杜娟，刘雪来. 表皮干细胞在糖尿病伤口修复治疗中的作用[J]. 中华内分泌外科杂志，2016, 10(3):236-239.
[2]	杜娟，刘雪来. 表皮干细胞在糖尿病儿童伤口修复中的研究和思考[J]. 中华内分泌外科杂志，2015, 9(6):513-515.
[3]	杜娟，刘雪来. 表皮干细胞：治疗难愈性皮肤创面的种子细胞[J/CD]. 中华损伤与修复杂志(电子版), 2014, 9(6):664-667.
[58]	Sandri G, Aguzzi C, Rossi S, et al. Halloysite and chitosan oligosaccharide nanocomposite for wound healing[J]. Acta Biomater, 2017, 15(57):216-224.
[59]	Wiegand C, Winter D, Hipler UC. Molecular-weight-Dependent toxic effects of Chitosans on the human keratinocyte cell line HaCaT[J]. Skin Pharmacol Physiol, 2010, 23(1):164-170.
[60]	Wang Y, Zhang CL, Zhang Q, et al. Composite electrospun nanomembranes of fish scale collagen peptides/chito-oligosaccharides: antibacterial properties and potential for wound dressing[J]. Int J Nanomedicine, 2011, 6:667-676.
[4]	乔莹，白雪芳，杜昱光. 壳寡糖治疗骨质疏松症的研究进展[J]. 中国海洋药物，2011, 30(2):62-64.
[5]	张春，刘世清，张弩，等. 壳寡糖对体外培养液软骨细胞增殖的影响及对IL-1β诱导凋亡的保护作用[J/CD]. 中华临床医师杂志(电子版), 2013, 7(3):1108-1112.
[6]	刘红云，覃彩芹，李顺文，等. 壳寡糖对急性酒精性肝损伤保护作用的研究[J]. 中国现代医学杂志，2010, 20(3):350-353.
[61]	Ahn BN, Kim JA, Himaya SW, et al. Chitooligosaccharides attenuate UVB-induced damages in human dermal fibroblasts[J]. Naunyn Schmiedebergs Arch Pharmacol, 2012, 385(1):95-102.
[62]	Liu X, Lee PY, Ho CM, et al. Silver nanoparticles mediate differential responses in keratinocytes and fibroblasts during skin wound healing[J]. ChemMedChem, 2010, 5(3):468-475.
[63]	王红兵，张军，万希琴，等. 壳寡糖对糖尿病大鼠难愈感染创面的作用[J]. 中国海洋药物，2012, 31(6):33-36.
[7]	许青松，麻攀，魏鹏，等. 壳寡糖减弱乙醇对人胚胎肝细胞损伤的研究[J]．中国生化药物杂志，2008, 29(4):259-261.
[8]	刘洋，韩宝芹，刘万顺，等. 壳寡糖对酵母联合腺嘌呤致高尿酸血症小鼠的治疗作用[J]. 中国海洋大学学报(自然科学版), 2009, 39(S1):143-146.
[9]	Pan H, Yang Q, Huang G, et al. Hypolipidemic effects of chitosan and its derivatives in hyperlipidemic rats induced by a high-fat diet[J]. Food Nutr Res, 2016, 60:31137.
[64]	王海生，范廷英，任青华，等. 壳寡糖对小鼠微循环及移植性肿瘤的影响[J]．中国生化药物杂志，2005, 26(5):301-302.
[65]	Gong Y, Gong L, Gu X, et al. Chitooligosaccharides promote peripheral nerve regeneration in a rabbit common peroneal nerve crush injury model[J]. Microsurgery, 2009, 29(8):650-656.
[66]	Jiang M, Zhuge X, Yang Y, et al. The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model[J]. Neurosci Lett, 2009, 454(3):239-243.
[10]	Kumar SG, Rahman MA, Lee SH, et al.Plasma proteome analysis for anti-obesity and anti-diabetic potentials of chitosan oligosaccharides in ob/ob mice[J]. Proteomics, 2009, 9(8):2149-2162.
[11]	Yan YL, Hu Y, Simpson DJ, et al. Enzymatic Synthesis and Purification of Galactosylated Chitosan Oligosaccharides Reducing Adhesion of Enterotoxigenic Escherichia coli K88[J]. J Agric Food Chem, 2017, 65(25):5142-5150.
[12]	钱建瑛，丁振中，朱玉霞，等. 壳寡糖对大肠杆菌抑菌活性研究[J]. 工业微生物，2016, 46(6):13-19.
[67]	蒋茂荣，蒋志超，丁斐. 壳寡糖促神经元生长的作用[J]. 苏州大学学报(医学版), 2012, 32(6):749-753.
[68]	Du Juan, Liu Xuelai. Nano Biomaterials: A promising therapeutic strategy for skin wound healing in diabetic populations[J]. J Med Med Sci, 2017, 4(5):44-49.
[69]	Du Juan, Liu Xuelai. 3D-bioprinting, a promising technique to fabricate dermal equivalent for wound healing[J]. J Med Med Sci, 2017, 4(3):11-17.
[13]	Lee BC, Kim MS, Choi SH, et al. In vitro and in vivo antimicrobial activity of water-soluble chitosan oligosaccharides against Vibrio vulnificus[J]. Int J Mol Med, 2009, 24(3):327-333.
[14]	刘碧源，高仕瑛，李邦良，等. 壳寡糖抗菌活性的实验研究[J]. 中国生化药物杂志，2003, 24(2):73-75.
[15]	李昱，许青松，彭强，等. 壳寡糖抗炎作用研究进展[J]. 中国生化药物杂志，2012, 33(3):326-328.
[70]	杜娟，刘雪来. 3D生物打印技术在皮肤创面修复中的研究进展[J]. 中华创伤杂志，2014, 30(10):1063-1066.
[71]	杜娟，刘雪来. 诱导多潜能干细胞：治疗糖尿病的新种子细胞[J]. 中华内分泌外科杂志，2017, 11(3):236-253.
[72]	杜娟，刘雪来. 皮肤成纤维细胞"干"性特征及其在创伤治疗中的应用前景[J/CD]．中华损伤与修复杂志(电子版), 2018, 13(3):230-233.
[16]	Lu Y, Slomberg DL, Schoenfisch MH. Nitric oxide-releasing chitosan oligosaccharides as antibacterial agents[J]. Biomaterials, 2014, 35(5):1716-1724.
[17]	Tin S, Sakharkar KR, Lim CS, et al. Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa[J]. Int J Biol Sci, 2009, 5(2):153-160.
[18]	Liu X, Xia W, Jiang Q, et al. Effect of kojic acid-grafted-chitosan oligosaccharides as a novel antibacterial agent on cell membrane of gram-positive and gram-negative bacteria[J]. J Biosci Bioeng, 2015, 120(3):335-339.
[19]	Öhlknecht C, Tegl G, Beer B, et al. Cellobiose dehydrogenase and chitosan-based lysozyme responsive materials for antimicrobial wound treatment[J]. Biotechvnol Bioeng, 2017, 114(2):416-422.
[20]	Qiao Y, Bai XF, Du YG. Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress[J]. Int Immunopharmacol, 2011, 11(1):121-127.
[21]	乔莹，许青松，白雪芳，等. 壳寡糖减弱内毒素对小鼠巨噬细胞的损伤作用[J]. 中国生化药物杂志，2011, 32(2):136-138.
[22]	Kim JH, Kim YS, Hwang JW, et al. Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-κB inactivation[J]. Molecules, 2014, 19(11):18232-18247.
[23]	Liu HT, Huang P, Ma P, et al. Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human unbilical vein endothelial cells through blockade of p38 and Akt protein kinases[J]. Acta Pharmacologica Sin, 2011, 32(4):478-486.
[24]	Li Y, Xu Q, Wei P, et al. Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling[J]. Int J Mol Med, 2014, 33(2):392-400.
[25]	李昱，许青松，魏鹏，等．壳寡糖抑制脂多糖诱导的PIECs表达IL-8和VCAM-1作用的初步研究[J]. 现代生物医学进展，2013, 13(34):6601-6604.
[26]	Yang JW, Tian G, Chen DW, et al. Involvement of PKA signalling in anti-inflammatory effects of chitosan oligosaccharides in IPEC-J2 porcine epithelial cells[J]. J Anim Physiol Anim Nutr (Berl), 2018, 102(1):252-259.
[27]	Kunanusornchai W, Witoonpanich B, Tawonsawatruk T, et al. Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: An in vitro and in vivo study[J]. Pharmacol Res, 2016, 113(Pt A):458-467.

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