Debridement is the basic and key step of wound treatment. The basic point is to removes necrotic tissues and contaminated foreign matter completely, and promotes wound healing. According to different treatment methods, debridement can be divided into surgical debridement, mechanical debridement, autolysis debridement, enzymatic debridement, biological debridement etc. All of these debridement methods have advantages and shortcomings in clinical application. Recent years, a number of new debridement techniques have emerged, such as hydrodynamic debridement and low-temperature plasma radiofrequency ablation debridement, which make up for the deficiency of traditional debridement methods. These new methods can remove contaminated or necrotic tissue accurately, and minimize damage to the surrounding normal tissues. The concept of precise debridement has been developed to target the removal of necrotic and unhealthy tissues, to maximize the retention of normal tissue, and to alleviate pain during debridement. This article reviews the current clinical debridement methods and the new techniques which can achieve accurate debridement.