Research progress of circular RNA in cutaneous diseases and wound healing

doi:10.3877/cma.j.issn.1673-9450.2020.04.016

Abstract

Abstract:

Circular RNA(circRNA) is a novel class of non-coding RNA that assumes a covalently closed continuous loop without 3′ and 5′ free terminus. Some circRNA can serve as microRNA (miRNA) sponges, regulate transcription or splicing, and can interact with RNA binding proteins, thus playing pivotal roles in both physiological and pathological process. Recent studies suggest that circRNA has been involved in cellular activities like proliferation and migration of vascular endothelial cells and keratinocytes, which are associated with wound healing. This article reviewed the roles of circRNA in regulation of different types of skin cells, as well as its interaction with skin diseases like cutaneous squamous cell carcinoma, basal cell carcinoma and severe acne, with the purpose to propose new insights on the cellular and molecular mechanism of wound healing, and to exploit a novel direction in the solution to conundrums of clinical wound management.

Key words: Wound healing, Skin diseases, Cicatrix, Cells, Circular RNA

Shaoshuo Yu, Jian Jin, Fei He, Zhaofan Xia. Research progress of circular RNA in cutaneous diseases and wound healing[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(04): 312-315.

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