Research progress on skin from genetically engineered pigs

doi:10.3877/cma.j.issn.1673-9450.2022.02.014

Abstract

Abstract:

The use of allogeneic skin (or xeno-skin) to cover the burn wound is one of the key measure for extensive burn treatment. When allogeneic skin is not easy to obtain, temporary covering of the wound with xenograft of skin, especially pig skin, can also play a certain therapeutic effect. Due to the immune barrier between species, ordinary pig skin covers the human wound for a short time and cannot form vascularization with the wound. In recent years, genetic modification of donor pigs through genetic engineering, including gene knockout and gene transfer, can reduce the rejection of transplants by the human to a certain extent and prolong the survival time of xenografts. This article reviews the research progress of genetically engineered pig skin for xenotransplantation.

Key words: Skin transplantation, Swine, Xenotransplantation, Genetic engineering

Feng Li, Junyou Li. Research progress on skin from genetically engineered pigs[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(02): 163-166.

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