Research progress of chitosan composite scaffolds for repair of articular cartilage defect

doi:10.3877/cma.j.issn.1673-9450.2022.06.013

Abstract

Abstract:

Articular cartilage defects is a common clinical disease, which can cause osteoarthritis in severe cases and bring great pain to patients. At present, the common clinical treatment methods can not form wear resistant, pressure resistant articular cartilage, and can not maintain the normal function of new cartilage for a long time. Therefore, there is an urgent need to find a novel method for the repair of articular cartilage defects. In recent years, tissue engineering technology provides a new and potential idea and means in the repair of articular cartilage defects. Among them, the design and development of new biological scaffold materials for articular cartilage defect repair has become a key. Among many natural materials, chitosan not only has good biocompatibility, biological activity, degradability, but also has a wide range of sources and low price. More importantly, its structure is similar to that of extracellular matrix glycosaminoglycan of articular cartilage, so it has become a promising tissue engineering scaffold material for the repair of articular cartilage defects. In addition, chitosan can be combined with other biomaterials, so the preparation of chitosan composite scaffolds for articular cartilage defect repair has received much attention. In this review, the properties of chitosan materials used in the repair of articular cartilage defects and the application of chitosan composite scaffold materials in the repair of articular cartilage defects are summarized, and the prospects of chitosan composite scaffolds for articular cartilage tissue engineering in the future are prospected.

Key words: Cartilage, articular, Chitosan, Tissue engineering, Chitosan composite scaffold

Xiandong Kuai, Guoshuang Zheng, Jiahui Yang, Dewei Zhao. Research progress of chitosan composite scaffolds for repair of articular cartilage defect[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(06): 535-539.

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References 47

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