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Chinese Journal of Injury Repair and Wound Healing(Electronic Edition) ›› 2024, Vol. 19 ›› Issue (06): 467-473. doi: 10.3877/cma.j.issn.1673-9450.2024.06.003

• Original Articles • Previous Articles     Next Articles

Causal relationship and mediating effect between knee osteoarthritis related inflammatory factors and plasma metabolites

Zhenyu Wang1, Hongmei Zhang1,(), Lin Jing1, Mingjiang He1, Qi Yan1   

  1. 1.The First Department of Bone and Joint Diseases, Wangjing Hospital, China Academy of Chinese Medical Sciences,Beijing 100102, China
  • Received:2024-09-18 Online:2024-12-01 Published:2024-12-02
  • Contact: Hongmei Zhang

Abstract:

Objective

To evaluate the causal relationship between inflammatory factors, plasma metabolites and knee osteoarthritis (KOA) and the mediating effect of plasma metabolites in inflammatory factor-mediated KOA using Mendelian randomization (MR) system.

Methods

The genome-wide association study (GWAS) data of 91 inflammatory factors, 1 400 plasma metabolites and KOA were obtained from the public GWAS database.Two-sample MR analysis was used to evaluate the causal relationship between inflammatory factors, metabolites and KOA and KOA-related inflammatory factors and metabolites, and then the mediating effect of metabolites in inflammatory factor-mediated KOA was estimated.

Results

2 inflammatory factors (CD5, FGF-5) and 65 plasma metabolites were found to have significant causal relationships with KOA.Mediation analysis found that N-acetyl-1-methylhistidine had a 3.7% mediating effect ratio in the causal relationship between FGF-5 and KOA.

Conclusion

A variety of inflammatory factors and metabolites have a causal relationship with KOA, and the effect of metabolism on KOA should be paid attention to.The role of T cells in the prevention of KOA is confirmed, and the anti-inflammatory effect of leukocyte-rich platelet-rich plasma is explained from the genetic level.The potential of FGF pathway to prevent KOA is identified, which provides a reference for future studies of PRP components.

Key words: Osteoarthritis,knee, Chemokines, Platelet-rich plasma, Mendelian randomization analysis, Plasma metabolites, Mediation analysis

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