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中华损伤与修复杂志(电子版) ›› 2021, Vol. 16 ›› Issue (04) : 353 -357. doi: 10.3877/cma.j.issn.1673-9450.2021.04.013

综述

成纤维细胞的异质性及其在创面愈合和瘢痕形成中的作用
王珏1, 胡晓红1, 贺伟峰1,()   
  1. 1. 400038 重庆,陆军军医大学(第三军医大学)第一附属医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验室,重庆市疾病蛋白质组学重点实验室
  • 收稿日期:2021-05-19 出版日期:2021-08-05
  • 通信作者: 贺伟峰

Role of fibroblasts heterogeneity in wound healing and scar formation

Jue Wang1, Xiaohong Hu1, Weifeng He1,()   

  1. 1. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, First Affiliated Hospital of Army Medical University (Third Military Medical University), Chongqing Key Laboratory for Disease Proteomics, Chongqing 400038, China
  • Received:2021-05-19 Published:2021-08-05
  • Corresponding author: Weifeng He
引用本文:

王珏, 胡晓红, 贺伟峰. 成纤维细胞的异质性及其在创面愈合和瘢痕形成中的作用[J/OL]. 中华损伤与修复杂志(电子版), 2021, 16(04): 353-357.

Jue Wang, Xiaohong Hu, Weifeng He. Role of fibroblasts heterogeneity in wound healing and scar formation[J/OL]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2021, 16(04): 353-357.

成纤维细胞是创面愈合过程中重要的效应细胞之一,参与了多个重要环节。成纤维细胞的不同亚群根据其解剖定位、细胞表面标志和功能表型等不同方面表现出强烈的异质性,本文就成纤维细胞的异质性特点及其在创面愈合及瘢痕形成中的作用作一综述,旨在在为创面修复治疗提供新的理论基础。

Fibroblasts are one of the important effector cells in the wound healing process and are involved in several important aspects. Different subpopulations of fibroblasts exhibit strong heterogeneity depending on different aspects of their anatomical localization, cell surface markers, and functional phenotypes. This paper reviews the heterogeneous characteristics of fibroblasts and their role in wound healing and scar formation, with the aim of providing a new theoretical basis for wound repair therapy.

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