Research progress of mesenchymal stem cell-derived exosomes in wound repair

doi:10.3877/cma.j.issn.1673-9450.2020.01.012

Abstract

Abstract:

Exosomes are a vesicle structure with a diameter of about 30 to 100 nm produced by cells through the paracrine pathway. As a subcellular component secreted by living cells, exosomes are widely involved in the communication of information between cells. A number of studies have shown that exosomes derived from mesenchymal stem cells regulate multiple processes of wound repair. It can promote the repair and regeneration of wounds by inhibiting the excessive inflammation response of the wound, promoting the angiogenesis of the wound, promoting the proliferation and migration of fibroblasts, and inhibiting the formation of wound scars. This article reviews the role of mesenchymal stem cell-derived exosomes in wound repair and related mechanisms, and provides a basis for clinical application of exosomes.

Key words: Exosomes, Stem cells, Wound healing, Inflammation, Cicatrix, Angiogenesis

Hongyu Wang, Lingying Liu, Te Ba. Research progress of mesenchymal stem cell-derived exosomes in wound repair[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(01): 67-69.

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