General situation of research on hydrogen sulfide and its relation with intracellular calcium ions

doi:10.3877/cma.j.issn.1673-9450.2020.01.013

Abstract

Abstract:

Hydrogen sulfide, as a new type of gas signaling molecule, is widely involved in the physiological activities of various systems of the body. Hydrogen sulfide can change the concentration of calcium ions in cells and have a certain effect on the functional state of cells. In epidermal cells, there are systems of cystethioether -γ-lyase and cystethioether-β-synthase. Burn stress can inhibit the function of hydrogen sulfide/cystethioether-γ-lyase system in rat epidermal cells and reduce hydrogen sulfide production. Severe burn stress caused the dysfunction of various organs. And the reperfusion injury caused the body to produce a large amount of oxygen free radicals at the same time. The activation of various enzymes and the release of inflammatory factors can aggravate the edema of cells, and calcium ion overload occurs in the cells. Therefore, it is of great significance to study the mechanism of action of hydrogen sulfide on epidermal cells, and to further explore whether hydrogen sulfide is mediated by calcium ions in epidermal cells. This paper summarizes the current domestic and foreign studies in order to enrich the theoretical basis of hydrogen sulfide function research, study the correlation between hydrogen sulfide and intracellular calcium ion concentration to explore calcium ions whether it plays a certain role in the intracellular signal pathway of hydrogen sulfide.

Key words: Hydrogen sulfide, Burns, Second messenger systems, Calcium ion

Congmo Shen, Yi Li. General situation of research on hydrogen sulfide and its relation with intracellular calcium ions[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2020, 15(01): 70-72.

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