To evaluate the efficacy of the combined application of local injection of compound Betamethasone and human-like collagen scar repair gel in the treatment of hypertrophic scar.

Seventy patients with hypertrophic scar were admitted to Shenyang Jishuitan Hospital from December 2018 to October 2020 were divided into experimental group and control group according to the random number table method, 35 patients in each group. The experimental group were treated with the local injection of compound Betamethasone combined with human-like collagen scar repair gel. Compound Betamethasone(≤40 mg) was injected into the scar until the scar was bulging and slightly white, once every four weeks. From the second day after each injection, the human-like collagen scar repair gel(1-2 mg) was applied on the surface of the scar, twice a day. After the scar was reduced and flattened, the injection was stopped and the human-like collagen scar repair gel was only appied. One course of treatment needed 3 to 4 injections. In the control group, patients were treated simply with the local injection of compound Betamethasone and the method and dose were the same as the experimental group. Inject once every 4 weeks and stop the treatment after the scar was flatten. One course of treatment needed 3 to 4 injections. The occurrence of adverse reactions during the treatment of the two groups of patients was observed; the time when the scars became flat and the color was close to normal skin were observed; the clinical efficacy of the patients was judged 16 weeks after treatment and the patients were followed up for six months to record the recurrence of scars. Data were compared with t test and chi-square test.

During the treatment, there was 1 case of skin atrophy and 1 case of folliculitis in the experimental group, and the incidence of adverse reactions was 57%. In the control group, there was 1 case of skin atrophy and 2 cases of folliculitis, with an adverse reaction rate of 8.6%, and there was no statistically significant difference between the two groups(χ²=0.001, P>0.05). The time of scar flattening in the experimental group was (4.50±2.80) weeks, and the time of scar color approaching normal skin was (7.5±2.7) weeks, the time of scar flattening in the control group was (6.23±2.80) weeks, and the time of scar color approaching normal skin was (14.5±4.7) weeks, there were statistically significant differences between the two groups (t=8.312, 12.532; P<0.05). After 16 weeks of treatment in the experimental group, 28 cases were significantly affected, 5 cases were effective, and 2 cases were ineffective, the total effective rate of treatment was 94.3%; in control group 30 cases were significantly affected, 4 cases were effective, and 1 cases were ineffective, the total effective rate of treatment was 94.3%. There was no significant difference between the two groups (χ²=0.001, P>0.05). After half a year of follow-up, the scar recurrence rate was 3.0% (1/33) in the experimental group and 11.8% (4/34) in the control group. The difference between the two groups was statistically significant (χ²=3.858, P<0.05).

Local injection of compound Betamethasone injection combined with human-like collagen scar repair gel for the treatment of hypertrophic scars has the advantages of low recurrence rate, shorter scars flattening time and shorter color recovery time, which is worthy of promotion.