Research progress of adipose mesenchymal stem cell exosomes promoting wound angiogenesis

doi:10.3877/cma.j.issn.1673-9450.2022.02.012

Abstract

Abstract:

Wound healing is a complex process for cells and tissues to repair after revascularization of injury, in which angiogenesis is the key to wound therapy. Promoting angiogenesis can accelerate wound healing effectively. Studies have shown that adipose-derived mesenchymal stem cells (ADSC) can effectively promote angiogenesis, whose exosomes (Exo) can deliver various cytokines and miRNAs. They can effectively promote the progressments of proliferation, migration and tubular formation of vascular endothelial cells. This paper will review the domestic and foreign studies on the role of ADSC-Exo in promoting wound angiogenesisand its mechanism, and discusse the role of ADSC-Exo in promoting vascular regeneration from three aspects: the role of promoting wound healing, the mechanism and the strategy of ADSC-Exo delivery of various biological materials to provide new ideas for wound treatment.

Key words: Mesenchymal stem cells, Exosomes, Wound healing, Angiogenesis, Biological materials

Tao Cao, Ke Tao. Research progress of adipose mesenchymal stem cell exosomes promoting wound angiogenesis[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2022, 17(02): 154-158.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhssyxfzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1673-9450.2022.02.012

https://zhssyxfzz.cma-cmc.com.cn/EN/Y2022/V17/I02/154

References 40

[1]	Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes[J]. Science, 2020, 367(6478): eaau6977.
[2]	Li X, Xie X, Lian W, et al. Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model [J]. Exp Mol Med, 2018, 50(4): 1-14.
[3]	Xiao S, Xiao C, Miao Y, et al. Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing[J]. Stem Cell Res Ther, 2021, 12(1): 255.
[4]	Wang C, Wang M, Xu T, et al. Engineering Bioactive Self-Healing Antibacterial Exosomes Hydrogel for Promoting Chronic Diabetic Wound Healing and Complete Skin Regeneration[J]. Theranostics, 2019, 9(1): 65-76.
[5]	Bacakova L, Zarubova J, Travnickova M, et al. Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review[J]. Biotechnol Adv, 2018, 36(4): 1111-1126.
[6]	Gadelkarim M, Abushouk AI, Ghanem E, et al. Adipose-derived stem cells: Effectiveness and advances in delivery in diabetic wound healing[J]. Biomed Pharmacother, 2018, 107: 625-633.
[7]	Wu Y, Huang S, Enhe J, et al. Bone marrow-derived mesenchymal stem cell attenuates skin fibrosis development in mice [J]. Int Wound J, 2014, 11(6): 701-710.
[8]	Cai Y, Li J, Jia C, et al. Therapeutic applications of adipose cell-free derivatives: a review [J]. Stem Cell Res Ther, 2020, 11(1): 312.
[9]	Xing X, Han S, Cheng G, et al. Proteomic Analysis of Exosomes from Adipose-Derived Mesenchymal Stem cells: A Novel Therapeutic Strategy for Tissue Injury [J]. Biomed Res Int, 2020, 2020: 6094562.
[10]	Pomatto M, Gai C, Negro F, et al. Differential Therapeutic Effect of Extracellular Vesicles Derived by Bone Marrow and Adipose Mesenchymal Stem cells on Wound Healing of Diabetic Ulcers and Correlation to Their Cargoes [J]. Int J Mol Sci, 2021, 22(8): 3851.
[11]	Phinney DG, Pittenger MF. Concise Review: MSC-Derived Exosomes for Cell-Free Therapy [J]. Stem cell, 2017, 35(4): 851-858.
[12]	Wu P, Zhang B, Shi H, et al. MSC-Exosome: A novel cell-free therapy for cutaneous regeneration [J]. Cytotherapy, 2018, 20(3): 291-301.
[13]	Hu P, Yang Q, Wang Q, et al. Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration [J]. Burns & trauma, 2019, 7: 38.
[14]	Karaman S, Leppänen VM, Alitalo K. Vascular endothelial growth factor signaling in development and disease[J]. Development (Cambridge, England), 2018, 145(14): dev151019.
[15]	Si Z, Wang X, Sun C, et al. Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies [J]. Biomed Pharmacother, 2019, 114: 108765.
[16]	Kranendonk ME, Visseren FL, van Balkom BW, et al. Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages [J]. Obesity (Silver Spring, Md), 2014, 22(5): 1296-1308.
[17]	Kang T, Jones TM, Naddell C, et al. Adipose-Derived Stem cells Induce Angiogenesis via Microvesicle Transport of miRNA-31 [J]. Stem cell Transl Med, 2016, 5(4): 440-450.
[18]	Zhao L, Johnson T, Liu D. Therapeutic angiogenesis of adipose-derived stem cells for ischemic diseases [J]. Stem Cell Res Ther, 2017, 8(1): 125.
[19]	Chen B, Cai J, Wei Y, et al. Exosomes Are Comparable to Source Adipose Stem Cells in Fat Graft Retention with Up-Regulating Early Inflammation and Angiogenesis [J]. Plast Reconstr Surg, 2019, 144(5): 816e-827e.
[20]	Liang X, Zhang L, Wang S, et al. Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a [J]. J Cell Sci, 2016, 129(11): 2182-2189.
[21]	Zhu D, Johnson TK, Wang Y, et al. Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb [J]. Stem Cell Res Ther, 2020, 11(1): 162.
[22]	Wang L, Hu L, Zhou X, et al. Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling [J]. Sci Rep, 2017, 7(1): 13321.
[23]	Choi EW, Seo MK, Woo EY, et al. Exosomes from human adipose-derived stem cells promote proliferation and migration of skin fibroblasts [J]. Exp Dermatol, 2018, 27(10): 1170-1172.
[24]	Zhang W, Bai X, Zhao B, et al. Cell-free therapy based on adipose tissue stem cell-derived exosomes promotes wound healing via the PI3K/Akt signaling pathway [J]. Exp Cell Res, 2018, 370(2): 333-342.
[25]	王江文，易阳艳，朱元正，等. 脂肪干细胞来源外泌体促进糖尿病小鼠创面愈合的实验研究[J]. 中国修复重建外科杂志，2020, 34(1): 124-131.
[26]	Xu H, Wang Z, Liu L, et al. Exosomes derived from adipose tissue, bone marrow, and umbilical cord blood for cardioprotection after myocardial infarction[J]. J Cell Biochem, 2020, 121(3): 2089-2102.
[27]	胡玄，易阳艳，朱元正，等. 脂肪干细胞来源外泌体促进大鼠皮瓣移植后血管新生的研究[J]. 中国修复重建外科杂志，2019, 33(12): 1560-1565.
[28]	Han YD, Bai Y, Yan XL, et al. Co-transplantation of exosomes derived from hypoxia-preconditioned adipose mesenchymal stem cells promotes neovascularization and graft survival in fat grafting [J]. Biochem Biophys Res Commun, 2018, 497(1): 305-312.
[29]	Han Y, Ren J, Bai Y, et al. Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF/VEGF-R [J]. Int J Biochem Cell Biol, 2019, 109: 59-68.
[30]	张静，易阳艳，阳水发，等. 脂肪干细胞来源外泌体对人脐静脉血管内皮细胞增殖、迁移及管样分化的影响[J]. 中国修复重建外科杂志，2018, 32(10): 1351-1357.
[31]	Ren S, Chen J, Duscher D, et al. Microvesicles from human adipose stem cells promote wound healing by optimizing cellular functions via AKT and ERK signaling pathways [J]. Stem Cell Res Ther, 2019, 10(1): 47.
[32]	Xiong Y, Chen L, Yan C, et al. Circulating Exosomal miR-20b-5p Inhibition Restores Wnt9b Signaling and Reverses Diabetes-Associated Impaired Wound Healing [J]. Small, 2020, 16(3): e1904044.
[33]	Shi R, Jin Y, Hu W, et al. Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy [J]. Am J Physiol Cell Physiol, 2020, 318(5): C848-c856.
[34]	Xu F, Xiang Q, Huang J, et al. Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu [J]. Stem Cell Res Ther, 2019, 10(1): 106.
[35]	Yang Y, Cai Y, Zhang Y, et al. Exosomes Secreted by Adipose-Derived Stem cells Contribute to Angiogenesis of Brain Microvascular Endothelial cell Following Oxygen-Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis [J]. J Mol Neurosci, 2018, 65(1): 74-83.
[36]	Xue C, Shen Y, Li X, et al. Exosomes Derived from Hypoxia-Treated Human Adipose Mesenchymal Stem cells Enhance Angiogenesis Through the PKA Signaling Pathway [J]. Stem cell Dev, 2018, 27(7): 456-465.
[37]	Du L, Li G, Yang Y, et al. Exosomes from microRNA-199-3p-modified adipose-derived stem cells promote proliferation and migration of endothelial tip cells by downregulation of semaphorin 3A [J]. Int J Clin Exp Pathol, 2018, 11(10): 4879-4888.
[38]	Shiekh PA, Singh A, Kumar A. Exosomes laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing [J]. Biomaterials, 2020, 249: 120020.
[39]	Shafei S, Khanmohammadi M, Heidari R, et al. Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: An in vivo study [J]. J Biomed Mater Res A, 2020, 108(3): 545-556.
[40]	Xiong J, Liu Z, Wu M, et al. Comparison of Proangiogenic Effects of Adipose-Derived Stem cells and Foreskin Fibroblast Exosomes on Artificial Dermis Prefabricated Flaps [J]. Stem cell Int, 2020, 2020: 5293850.

Please choose a citation manager

Content to export